Pathophysiology of Age-related Hearing Loss (peripheral and Central)

Overview

Journal Korean J Audiol

Specialty Otorhinolaryngology

Date 2014 Mar 22

PMID 24653905

Citations 41

Authors

Kyu-Yup Lee

Affiliations

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Abstract

Age-related hearing loss (presbycusis) refers to bilaterally symmetrical hearing loss resulting from aging process. Presbycusis is a complex phenomenon characterized by audiometric threshold shift, deterioration in speech-understanding and speech-perception difficulties in noisy environments. Factors contributing to presbycusis include mitochondria DNA mutation, genetic disorders including Ahl, hypertension, diabetes, metabolic disease and other systemic diseases in the intrinsic aspects. Extrinsic factors include noise, ototoxic medication and diet. However, presbycusis may not be related to the intrinsic and extrinsic factors separately. Presbycusis affects not only the physical, cognitive and emotional activities of patients, but also their social functioning. As a result, patients' quality of life deteriorates, compounded by various symptoms including depression, social isolation and lower self-esteem. Presbycusis is classified into six categories, as based on results of audiometric tests and temporal bone pathology, established by Schuknecht (1993): sensory, neural, metabolic or strial, cochlear conductive, mixed and indeterminate types. Among these, metabolic presbycusis is the mainstay of presbycusis types. Age-related changes also develop in the central hearing system. Functional decline of the central auditory system, caused by aging, reduces speech-understanding in noisy background and increase temporal processing deficits in gap-detection measures. This study reviews the literature on the age-related hearing loss.

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References

Merchant S, Linthicum F, Nadol Jr J . Histopathology of the inner ear in DFNA9. Adv Otorhinolaryngol. 2000; 56:212-7. DOI: 10.1159/000059105. View

Heffner R, Heffner H . Sound localization, use of binaural cues and the superior olivary complex in pigs. Brain Behav Evol. 1989; 33(4):248-58. DOI: 10.1159/000115932. View

Idrizbegovic E, Viberg A, Bogdanovic N, Canlon B . Peripheral cell loss related to calcium binding protein immunocytochemistry in the dorsal cochlear nucleus in CBA/CaJ mice during aging. Audiol Neurootol. 2001; 6(3):132-9. DOI: 10.1159/000046820. View

Niu X, Trifunovic A, Larsson N, Canlon B . Somatic mtDNA mutations cause progressive hearing loss in the mouse. Exp Cell Res. 2007; 313(18):3924-34. DOI: 10.1016/j.yexcr.2007.05.029. View

Popelar J, Groh D, Pelanova J, Canlon B, Syka J . Age-related changes in cochlear and brainstem auditory functions in Fischer 344 rats. Neurobiol Aging. 2006; 27(3):490-500. DOI: 10.1016/j.neurobiolaging.2005.03.001. View

Kim S, Frisina D, Frisina R . Effects of age on contralateral suppression of distortion product otoacoustic emissions in human listeners with normal hearing. Audiol Neurootol. 2002; 7(6):348-57. DOI: 10.1159/000066159. View

Pauler M, SCHUKNECHT H, White J . Atrophy of the stria vascularis as a cause of sensorineural hearing loss. Laryngoscope. 1988; 98(7):754-9. DOI: 10.1288/00005537-198807000-00014. View

Chisolm T, Willott J, Lister J . The aging auditory system: anatomic and physiologic changes and implications for rehabilitation. Int J Audiol. 2003; 42 Suppl 2:2S3-10. View

Rabinowitz P, Wise Sr J, Mobo B, Antonucci P, Powell C, Slade M . Antioxidant status and hearing function in noise-exposed workers. Hear Res. 2002; 173(1-2):164-71. DOI: 10.1016/s0378-5955(02)00350-7. View

10.

Johnson K, Erway L, Cook S, Willott J, Zheng Q . A major gene affecting age-related hearing loss in C57BL/6J mice. Hear Res. 1998; 114(1-2):83-92. DOI: 10.1016/s0378-5955(97)00155-x. View

11.

SUGA F, Lindsay J . Histopathological observations of presbycusis. Ann Otol Rhinol Laryngol. 1976; 85(2 pt.1):169-84. DOI: 10.1177/000348947608500201. View

12.

Jalenques I, Burette A, Albuisson E, ROMAND R . Age-related changes in GFAP-immunoreactive astrocytes in the rat ventral cochlear nucleus. Hear Res. 1997; 107(1-2):113-24. DOI: 10.1016/s0378-5955(97)00026-9. View

13.

Johnson K, Longo-Guess C, Gagnon L, Yu H, Zheng Q . A locus on distal chromosome 11 (ahl8) and its interaction with Cdh23 ahl underlie the early onset, age-related hearing loss of DBA/2J mice. Genomics. 2008; 92(4):219-25. PMC: 2836023. DOI: 10.1016/j.ygeno.2008.06.007. View

14.

Gleich O . The distribution of N-acetylgalactosamine in the cochlear nucleus of the gerbil revealed by lectin binding with soybean agglutinin. Hear Res. 1994; 78(1):49-57. DOI: 10.1016/0378-5955(94)90043-4. View

15.

Nelson E, Hinojosa R . Presbycusis: a human temporal bone study of individuals with downward sloping audiometric patterns of hearing loss and review of the literature. Laryngoscope. 2006; 116(9 Pt 3 Suppl 112):1-12. DOI: 10.1097/01.mlg.0000236089.44566.62. View

16.

Gates G, Mills J . Presbycusis. Lancet. 2005; 366(9491):1111-20. DOI: 10.1016/S0140-6736(05)67423-5. View

17.

Johnsson L . Reissner's membrane in the human cochlea. Ann Otol Rhinol Laryngol. 1971; 80(3):425-38. DOI: 10.1177/000348947108000322. View

18.

Strange R, Spiteri M, Ramachandran S, Fryer A . Glutathione-S-transferase family of enzymes. Mutat Res. 2001; 482(1-2):21-6. DOI: 10.1016/s0027-5107(01)00206-8. View

19.

Sha S, Kanicki A, Dootz G, Talaska A, Halsey K, Dolan D . Age-related auditory pathology in the CBA/J mouse. Hear Res. 2008; 243(1-2):87-94. PMC: 2577824. DOI: 10.1016/j.heares.2008.06.001. View

20.

Johnson K, Gagnon L, Webb L, Peters L, Hawes N, Chang B . Mouse models of USH1C and DFNB18: phenotypic and molecular analyses of two new spontaneous mutations of the Ush1c gene. Hum Mol Genet. 2003; 12(23):3075-86. PMC: 2862298. DOI: 10.1093/hmg/ddg332. View