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Osteoarthritis Pathogenesis - a Complex Process That Involves the Entire Joint

Overview
Journal J Med Life
Specialty General Medicine
Date 2014 Mar 22
PMID 24653755
Citations 139
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Abstract

Osteoarthritis is the most common joint disorder and a major cause of disability with a major socio-economic impact. In these circumstances is very important to understand its pathogenesis. Although previous research focused primarily on changes in the articular cartilage, more recent studies have highlighted the importance of the subchondral bone, synovium, menisci, ligaments, periarticular muscles and nerves. Now osteoarthritis is viewed as a multifactorial disease affecting the whole joint.

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References
1.
Crema M, Roemer F, Zhu Y, Marra M, Niu J, Zhang Y . Subchondral cystlike lesions develop longitudinally in areas of bone marrow edema-like lesions in patients with or at risk for knee osteoarthritis: detection with MR imaging--the MOST study. Radiology. 2010; 256(3):855-62. PMC: 2923728. DOI: 10.1148/radiol.10091467. View

2.
Englund M, Roemer F, Hayashi D, Crema M, Guermazi A . Meniscus pathology, osteoarthritis and the treatment controversy. Nat Rev Rheumatol. 2012; 8(7):412-9. DOI: 10.1038/nrrheum.2012.69. View

3.
Pauli C, Grogan S, Patil S, Otsuki S, Hasegawa A, Koziol J . Macroscopic and histopathologic analysis of human knee menisci in aging and osteoarthritis. Osteoarthritis Cartilage. 2011; 19(9):1132-41. PMC: 3217905. DOI: 10.1016/j.joca.2011.05.008. View

4.
Roemer F, Neogi T, Nevitt M, Felson D, Zhu Y, Zhang Y . Subchondral bone marrow lesions are highly associated with, and predict subchondral bone attrition longitudinally: the MOST study. Osteoarthritis Cartilage. 2009; 18(1):47-53. PMC: 2818146. DOI: 10.1016/j.joca.2009.08.018. View

5.
Sun Y, Mauerhan D, Kneisl J, Norton H, Zinchenko N, Ingram J . Histological examination of collagen and proteoglycan changes in osteoarthritic menisci. Open Rheumatol J. 2012; 6:24-32. PMC: 3339434. DOI: 10.2174/1874312901206010024. View