Antidepressant Properties of Aqueous Macerate from Gladiolus Dalenii Corms

Overview

Journal Afr J Tradit Complement Altern Med

Specialty Rehabilitation Medicine

Date 2014 Mar 22

PMID 24653553

Citations 6

Authors

Gwladys Temkou Ngoupaye

Elisabeth Ngo Bum

Germain Sotoing Taiwe

Fleur Clarisse Okomolo Moto

Emmanuel Talla

Affiliations

Soon will be listed here.

Abstract

Background: Gladiolus dalenii Van Geel (Iridaceae) has been used for the treatment of depression and psychotic disorders in African traditional medicine. The aim of this study was to assess the effect of the aqueous extract from the corm of Gladiolus dalenii and its possible mechanisms of action.

Materials And Methods: We assessed the antidepressant properties of G. dalenii corm aqueous extract in mice, using the open field, forced swimming, and tail suspension tests. Spontaneous locomotor activity of mice given various doses of G. dalenii extract (per os) was determined in the open field, whereas immobility was evaluated in the other two tests.

Results: Extract maximal effect was observed at 15 mg/kg, as mice displayed a marked reduction in immobility time in both the forced swimming test (80%) and the tail suspension test (66%). In further studies aimed at investigating the mechanism of action of G. dalenii extract, the latter significantly antagonized the effect of N-methyl-D-aspartate (NMDA, 75 mg/kg) at both the doses 15 mg/kg (p<0.001) and 150 mg/kg (p=0.004). A significant reduction in immobility time was also observed following treatment with combinations of a sub-effective dose of extract (7.5 mg/kg) with either the NMDA receptor antagonist D-(-)-2-amino-7-phosphonoheptanoic acid (D-AP7, 50 mg/kg, P< 0.001), the serotonin reuptake inhibitor fluoxetine (5 and 10 mg/kg, P< 0.001 and P< 0.001 respectively), and the multi-target antidepressant imipramine (5 and 10 mg/kg, P< 0.001 and P< 0.001 respectively). Moreover, neither G. dalenii extract alone nor its combinations with NMDA ligands imipramine and fluoxetine enhanced mouse spontaneous locomotor activity.

Conclusion: Altogether, these results suggest that G. dalenii has antidepressant properties, probably mediated through interactions with NMDA, serotonin and/ or noradrenergic systems, and may justify its use in traditional medicine.

Citing Articles

Current Knowledge of the Antidepressant Activity of Chemical Compounds from L.

Matraszek-Gawron R, Chwil M, Terlecki K, Skoczylas M Pharmaceuticals (Basel). 2023; 16(1).

PMID: 36678554 PMC: 9860663. DOI: 10.3390/ph16010058.

Depression in Sub-Saharan Africa.

Gbadamosi I, Henneh I, Aluko O, Yawson E, Fokoua A, Koomson A IBRO Neurosci Rep. 2022; 12:309-322.

PMID: 35746974 PMC: 9210463. DOI: 10.1016/j.ibneur.2022.03.005.

Medicinal plants used in managing diseases of the respiratory system among the Luo community: an appraisal of Kisumu East Sub-County, Kenya.

Mailu J, Nguta J, Mbaria J, Okumu M Chin Med. 2020; 15:95.

PMID: 32905471 PMC: 7469313. DOI: 10.1186/s13020-020-00374-2.

Recent Studies on Anti-Depressant Bioactive Substances in Selected Species from the Genera and : A Systematic Review.

Matraszek-Gawron R, Chwil M, Terlecka P, Skoczylas M Pharmaceuticals (Basel). 2019; 12(4).

PMID: 31775329 PMC: 6958339. DOI: 10.3390/ph12040172.

Combined corticosterone treatment and chronic restraint stress lead to depression associated with early cognitive deficits in mice.

Ngoupaye G, Yassi F, Bahane D, Bum E Metab Brain Dis. 2017; 33(2):421-431.

PMID: 29199383 DOI: 10.1007/s11011-017-0148-4.

References

Novas M, Wolfman C, Medina J, De Robertis E . Proconvulsant and 'anxiogenic' effects of n-butyl beta carboline-3-carboxylate, an endogenous benzodiazepine binding inhibitor from brain. Pharmacol Biochem Behav. 1988; 30(2):331-6. DOI: 10.1016/0091-3057(88)90463-7. View

Hansen Jr C, Malecha M, Mackenzie T, Kroll J . Copper and zinc deficiencies in association with depression and neurological findings. Biol Psychiatry. 1983; 18(3):395-401. View

Przegalinski E, Tatarczynska E, Chojnacka-Wojcik E . Antidepressant-like effects of a partial agonist at strychnine-insensitive glycine receptors and a competitive NMDA receptor antagonist. Neuropharmacology. 1997; 36(1):31-7. DOI: 10.1016/s0028-3908(96)00157-8. View

Borsini F, Meli A . Is the forced swimming test a suitable model for revealing antidepressant activity?. Psychopharmacology (Berl). 1988; 94(2):147-60. DOI: 10.1007/BF00176837. View

Sousa F, Melo C, Monteiro A, Lima V, Gutierrez S, Pereira B . Antianxiety and antidepressant effects of riparin III from Aniba riparia (Nees) Mez (Lauraceae) in mice. Pharmacol Biochem Behav. 2004; 78(1):27-33. DOI: 10.1016/j.pbb.2004.01.019. View

Wu G . Amino acids: metabolism, functions, and nutrition. Amino Acids. 2009; 37(1):1-17. DOI: 10.1007/s00726-009-0269-0. View

Kugaya A, Sanacora G . Beyond monoamines: glutamatergic function in mood disorders. CNS Spectr. 2006; 10(10):808-19. DOI: 10.1017/s1092852900010403. View

Skolnick P, Layer R, Popik P, Nowak G, Paul I, Trullas R . Adaptation of N-methyl-D-aspartate (NMDA) receptors following antidepressant treatment: implications for the pharmacotherapy of depression. Pharmacopsychiatry. 1996; 29(1):23-6. DOI: 10.1055/s-2007-979537. View

Zhang Z . Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders. Life Sci. 2004; 75(14):1659-99. DOI: 10.1016/j.lfs.2004.04.014. View

10.

Cryan J, Mombereau C, Vassout A . The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. Neurosci Biobehav Rev. 2005; 29(4-5):571-625. DOI: 10.1016/j.neubiorev.2005.03.009. View

11.

Bromet E, Andrade L, Hwang I, Sampson N, Alonso J, de Girolamo G . Cross-national epidemiology of DSM-IV major depressive episode. BMC Med. 2011; 9:90. PMC: 3163615. DOI: 10.1186/1741-7015-9-90. View

12.

Poleszak E, Wlaz P, Szewczyk B, Kedzierska E, Wyska E, Librowski T . Enhancement of antidepressant-like activity by joint administration of imipramine and magnesium in the forced swim test: Behavioral and pharmacokinetic studies in mice. Pharmacol Biochem Behav. 2005; 81(3):524-9. DOI: 10.1016/j.pbb.2005.03.017. View

13.

Sakakibara H, Ishida K, Grundmann O, Nakajima J, Seo S, Butterweck V . Antidepressant effect of extracts from Ginkgo biloba leaves in behavioral models. Biol Pharm Bull. 2006; 29(8):1767-70. DOI: 10.1248/bpb.29.1767. View

14.

Willner P . The validity of animal models of depression. Psychopharmacology (Berl). 1984; 83(1):1-16. DOI: 10.1007/BF00427414. View

15.

Maj J, Rogoz Z, Skuza G, SOWINSKA H . The effect of CGP 37849 and CGP 39551, competitive NMDA receptor antagonists, in the forced swimming test. Pol J Pharmacol Pharm. 1992; 44(4):337-46. View

16.

Andlin-Sobocki P, Wittchen H . Cost of affective disorders in Europe. Eur J Neurol. 2005; 12 Suppl 1:34-8. DOI: 10.1111/j.1468-1331.2005.01195.x. View

17.

Trullas R, Skolnick P . Functional antagonists at the NMDA receptor complex exhibit antidepressant actions. Eur J Pharmacol. 1990; 185(1):1-10. DOI: 10.1016/0014-2999(90)90204-j. View

18.

Lepine J, Briley M . The increasing burden of depression. Neuropsychiatr Dis Treat. 2011; 7(Suppl 1):3-7. PMC: 3131101. DOI: 10.2147/NDT.S19617. View

19.

Szewczyk B, Poleszak E, Wlaz P, Wrobel A, Blicharska E, Cichy A . The involvement of serotonergic system in the antidepressant effect of zinc in the forced swim test. Prog Neuropsychopharmacol Biol Psychiatry. 2009; 33(2):323-9. DOI: 10.1016/j.pnpbp.2008.12.011. View

20.

Steru L, Chermat R, Thierry B, Simon P . The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology (Berl). 1985; 85(3):367-70. DOI: 10.1007/BF00428203. View