Beta-protein Amyloid is Widely Distributed in the Central Nervous System of Patients with Alzheimer's Disease

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 1989 Feb 1

PMID 2464938

Citations 85

Authors

K Ogomori

T Kitamoto

J Tateishi

Y Sato

M Suetsugu

M Abe

Affiliations

Soon will be listed here.

Abstract

To clarify the distribution, morphology, and density of amyloid deposits in patients with Alzheimer's disease (AD), tissue sections from various areas of the central nervous system of 14 patients with AD and from 20 nondemented aged controls were investigated immunohistochemically using anti-beta protein antiserum. beta-protein amyloid deposits were present not only in the cores of the senile plaques and in the vascular wall (amyloid angiopathy), but also in various sized plaque-shaped fibrillary, perivascular, subpial, and subependymal deposits. Amyloid deposits were found mainly in the cerebral cortex in nondemented controls, while in AD they were distributed widely in the regions that were not affected in nondemented controls. The positivity of amyloid deposits in AD was 100% in the cerebral cortex, hippocampus, amygdala, thalamus, caudate nucleus, claustrum, hypothalamus, nucleus basalis of Meynert, and cerebellar cortex. Putamen and brain-stem nuclei were affected frequently, and the spinal cord, dentate nucleus, and globus pallidus were sometimes (less than 50%) affected. This result provides an evidence that Alzheimer's disease is a beta-protein amyloidosis of the central nervous system. An assessment of the distribution of amyloid deposits should prove to be useful for the histopathologic diagnosis of AD.

Citing Articles

Alzheimer's Disease: Understanding Motor Impairments.

Andrade-Guerrero J, Martinez-Orozco H, Villegas-Rojas M, Santiago-Balmaseda A, Delgado-Minjares K, Perez-Segura I Brain Sci. 2024; 14(11).

PMID: 39595817 PMC: 11592238. DOI: 10.3390/brainsci14111054.

Animal models of Alzheimer's disease: Current strategies and new directions.

Wang Q, Zhu B, Lei P Zool Res. 2024; 45(6):1385-1407.

PMID: 39572020 PMC: 11668949. DOI: 10.24272/j.issn.2095-8137.2024.274.

Progressive cervical cord atrophy parallels cognitive decline in Alzheimer's disease.

Emmenegger T, Seiler R, Unschuld P, Freund P, Klohs J Sci Rep. 2024; 14(1):21595.

PMID: 39284823 PMC: 11405669. DOI: 10.1038/s41598-024-67389-9.

Cytokine enrichment in deep cerebellar nuclei is contributed by multiple glial populations and linked to reduced amyloid plaque pathology.

Gaunt J, Zainolabidin N, Yip A, Tan J, Low A, Chen A J Neuroinflammation. 2023; 20(1):269.

PMID: 37978387 PMC: 10656954. DOI: 10.1186/s12974-023-02913-8.

Increased Heat Pain Tolerance but Hyperalgesia to Tonic Inflammatory Pain in the CRND8 Mouse Model of Alzheimer's Disease.

Merlo S, Costa L, Chiechio S, Busceti C, Ciranna L, Santangelo R J Alzheimers Dis. 2023; 96(1):77-91.

PMID: 37742639 PMC: 10657672. DOI: 10.3233/JAD-230148.

References

Roth M, Tomlinson B, Blessed G . Correlation between scores for dementia and counts of 'senile plaques' in cerebral grey matter of elderly subjects. Nature. 1966; 209(5018):109-10. DOI: 10.1038/209109a0. View

Schwartz P, KURUCZ J, KURUCZ A . RECENT OBSERVATIONS ON SENILE CEREBRAL CHANGES AND THEIR PATHOGENESIS. J Am Geriatr Soc. 1964; 12:908-22. DOI: 10.1111/j.1532-5415.1964.tb00640.x. View

Tomlinson B, Blessed G, Roth M . Observations on the brains of non-demented old people. J Neurol Sci. 1968; 7(2):331-56. DOI: 10.1016/0022-510x(68)90154-8. View

Avrameas S, Ternynck T . The cross-linking of proteins with glutaraldehyde and its use for the preparation of immunoadsorbents. Immunochemistry. 1969; 6(1):53-66. DOI: 10.1016/0019-2791(69)90178-5. View

Avrameas S, Taudou B, Chuilon S . Glutaraldehyde, cyanuric chloride and tetrazotized O-dianisidine as coupling reagents in the passive hemagglutination test. Immunochemistry. 1969; 6(1):67-76. DOI: 10.1016/0019-2791(69)90179-7. View

Tomlinson B, Blessed G, Roth M . Observations on the brains of demented old people. J Neurol Sci. 1970; 11(3):205-42. DOI: 10.1016/0022-510x(70)90063-8. View

Pro J, Smith C, SUMI S . Presenile Alzheimer disease: amyloid plaques in the cerebellum. Neurology. 1980; 30(8):820-5. DOI: 10.1212/wnl.30.8.820. View

Glenner G, Wong C . Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun. 1984; 120(3):885-90. DOI: 10.1016/s0006-291x(84)80190-4. View

Ishino H, Higashi S, Chuta M, Ohta H . Juvenile Alzheimer's disease with myoclonus: amyloid plaques and grumose alteration in the cerebellum. Clin Neuropathol. 1984; 3(5):193-8. View

10.

Masters C, Simms G, Weinman N, Multhaup G, McDonald B, Beyreuther K . Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci U S A. 1985; 82(12):4245-9. PMC: 397973. DOI: 10.1073/pnas.82.12.4245. View

11.

Goldgaber D, Lerman M, MCBRIDE O, Saffiotti U, Gajdusek D . Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science. 1987; 235(4791):877-80. DOI: 10.1126/science.3810169. View

12.

Kang J, Lemaire H, Unterbeck A, Salbaum J, Masters C, Grzeschik K . The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature. 1987; 325(6106):733-6. DOI: 10.1038/325733a0. View

13.

Vakili S, Muller J . Juvenile Alzheimer's disease with cerebellar involvement. Arch Pathol Lab Med. 1987; 111(5):480-2. View

14.

Robakis N, Ramakrishna N, Wolfe G, Wisniewski H . Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides. Proc Natl Acad Sci U S A. 1987; 84(12):4190-4. PMC: 305050. DOI: 10.1073/pnas.84.12.4190. View

15.

Kitamoto T, Ogomori K, Tateishi J, Prusiner S . Formic acid pretreatment enhances immunostaining of cerebral and systemic amyloids. Lab Invest. 1987; 57(2):230-6. View

16.

Probst A, BRUNNSCHWEILER H, Lautenschlager C, Ulrich J . A special type of senile plaque, possibly an initial stage. Acta Neuropathol. 1987; 74(2):133-41. DOI: 10.1007/BF00692843. View

17.

Coria F, Castano E, Frangione B . Brain amyloid in normal aging and cerebral amyloid angiopathy is antigenically related to Alzheimer's disease beta-protein. Am J Pathol. 1987; 129(3):422-8. PMC: 1899825. View

18.

Kitamoto T, Tateishi J . Immunohistochemical confirmation of Creutzfeldt-Jakob disease with a long clinical course with amyloid plaque core antibodies. Am J Pathol. 1988; 131(3):435-43. PMC: 1880700. View

19.

Ogomori K, Kitamoto T, Tateishi J, Sato Y, Tashima T . Aging and cerebral amyloid: early detection of amyloid in the human brain using biochemical extraction and immunostain. J Gerontol. 1988; 43(6):B157-62. DOI: 10.1093/geronj/43.6.b157. View

20.

Hirano A, Zimmerman H . Silver impregnation of nerve cells and fibers in celloidin sections. A simple impregnation technique. Arch Neurol. 1962; 6:114-22. DOI: 10.1001/archneur.1962.00450200028003. View