Interleukin-13 and Its Receptors in Colorectal Cancer (Review)

Overview

Journal Biomed Rep

Specialty Biochemistry

Date 2014 Mar 21

PMID 24649010

Citations 15

Authors

Ru Zhou

Shiguang Qian

Xiaodong Gu

Zongyou Chen

Jianbin Xiang

Affiliations

Soon will be listed here.

Abstract

Interleukin (IL)-13 is an immunoregulatory cytokine secreted by numerous immune cells. Its functions are similar to those of IL-4 and they share a common receptor. This cytokine has been included in recent studies on human tumors and malignant diseases, evoking a scientific interest to investigate the role of IL-13 and its receptors as novel biomarkers and targets for therapy. Colorectal cancer is one of the most common human malignancies, its prognosis is not promising and the efficacy of molecular-targeted therapy has not been established. This review summarizes the currently available data on the role of IL-13 and its receptors in colorectal cancer, including the signaling pathways involved in mediating the effects of IL-13, the role of IL-13 and/or its receptors in the prediction of cancer and several drugs targeting IL-13 or its receptors that are currently under evaluation.

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