Temporomandibular Disorders in Patients with Schizophrenia Using Antipsychotic Agents: a Discussion Paper

Overview

Journal Drug Healthc Patient Saf

Publisher Dove Medical Press

Specialty Health Services

Date 2014 Mar 21

PMID 24648768

Citations 7

Authors

Arao Nogueira de Araujo

Marion Alves do Nascimento

Eduardo Ponde de Sena

Abrahao Fontes Baptista

Affiliations

Soon will be listed here.

Abstract

Patients with psychiatric problems show a tendency to develop temporomandibular disorders (TMD). Particularly, patients with schizophrenia are quite likely to have signs and symptoms of TMD due to the impairment of their oral health, the use of antipsychotic drugs, and other general health problems. In nonschizophrenic populations, TMD have been considered as the main cause of nondental pain in the orofacial region, involving mechanisms associated with changes in masticatory activity at the cortical and neuromuscular levels. Individuals with schizophrenia do not usually complain of pain, and TMD is misdiagnosed in this population. In this paper, we aimed to review the clinical aspects of TMD in people with schizophrenia on antipsychotic drug therapy.

Citing Articles

Understanding Occlusion and Temporomandibular Joint Function Using Deep Learning and Predictive Modeling.

Farook T, Dudley J Clin Exp Dent Res. 2024; 10(6):e70028.

PMID: 39563180 PMC: 11576518. DOI: 10.1002/cre2.70028.

Genetically predicted major depression causally increases the risk of temporomandibular joint disorders.

Wu S, Chen Z, Zhao Y, He Q, Yin Z, Yao H Front Genet. 2024; 15:1395219.

PMID: 38836036 PMC: 11148344. DOI: 10.3389/fgene.2024.1395219.

The Effect of Antipsychotics on Cognition in Schizophrenia-A Current Narrative Review.

Lungu P, Lungu C, Ciobica A, Balmus I, Vitalaru R, Mavroudis I Brain Sci. 2024; 14(4).

PMID: 38672011 PMC: 11047912. DOI: 10.3390/brainsci14040359.

Amisulpride augmentation therapy improves cognitive performance and psychopathology in clozapine-resistant treatment-refractory schizophrenia: a 12-week randomized, double-blind, placebo-controlled trial.

Zhu M, Liu Z, Hu Q, Yang J, Jin Y, Zhu N Mil Med Res. 2022; 9(1):59.

PMID: 36253804 PMC: 9578180. DOI: 10.1186/s40779-022-00420-0.

Psychometric Properties of the Schizophrenia Oral Health Profile: Preliminary Results.

Denis F, Rouached I, Siu-Paredes F, Delpierre A, Amador G, El-Hage W Int J Environ Res Public Health. 2021; 18(17).

PMID: 34501679 PMC: 8430897. DOI: 10.3390/ijerph18179090.

References

Dworkin R . Pain insensitivity in schizophrenia: a neglected phenomenon and some implications. Schizophr Bull. 1994; 20(2):235-48. DOI: 10.1093/schbul/20.2.235. View

Yilmaz Z, Zai C, Hwang R, Mann S, Arenovich T, Remington G . Antipsychotics, dopamine D₂ receptor occupancy and clinical improvement in schizophrenia: a meta-analysis. Schizophr Res. 2012; 140(1-3):214-20. DOI: 10.1016/j.schres.2012.06.027. View

Chen J, Ondo W, Dashtipour K, Swope D . Tetrabenazine for the treatment of hyperkinetic movement disorders: a review of the literature. Clin Ther. 2012; 34(7):1487-504. DOI: 10.1016/j.clinthera.2012.06.010. View

Balasubramaniam R, Ram S . Orofacial movement disorders. Oral Maxillofac Surg Clin North Am. 2008; 20(2):273-85, vii. DOI: 10.1016/j.coms.2007.12.010. View

Jankelowitz S . Treatment of neurolept-induced tardive dyskinesia. Neuropsychiatr Dis Treat. 2013; 9:1371-80. PMC: 3783506. DOI: 10.2147/NDT.S30767. View

Goldstein B . Temporomandibular disorders: a review of current understanding. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999; 88(4):379-85. DOI: 10.1016/s1079-2104(99)70048-x. View

Saifee T, Edwards M . Tardive movement disorders: a practical approach. Pract Neurol. 2011; 11(6):341-8. DOI: 10.1136/practneurol-2011-000077. View

Singh M, Giles L, Nasrallah H . Pain insensitivity in schizophrenia: trait or state marker?. J Psychiatr Pract. 2006; 12(2):90-102. DOI: 10.1097/00131746-200603000-00004. View

McNeely M, Olivo S, Magee D . A systematic review of the effectiveness of physical therapy interventions for temporomandibular disorders. Phys Ther. 2006; 86(5):710-25. View

10.

Pekkan G, Kilicoglu A, Algin D . Treatment of a tardive dyskinesia patient with temporomandibular disorder: a case report. J Orofac Pain. 2010; 24(2):212-6. View

11.

Paesani D, Westesson P, Hatala M, Tallents R, Kurita K . Prevalence of temporomandibular joint internal derangement in patients with craniomandibular disorders. Am J Orthod Dentofacial Orthop. 1992; 101(1):41-7. DOI: 10.1016/0889-5406(92)70080-T. View

12.

McNeill C . Management of temporomandibular disorders: concepts and controversies. J Prosthet Dent. 1997; 77(5):510-22. DOI: 10.1016/s0022-3913(97)70145-8. View

13.

Winocur E, Hermesh H, Littner D, Shiloh R, Peleg L, Eli I . Signs of bruxism and temporomandibular disorders among psychiatric patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 103(1):60-3. DOI: 10.1016/j.tripleo.2006.03.019. View

14.

Undt G, Weichselbraun A, Wagner A, Kermer C, Rasse M . Recurrent mandibular dislocation under neuroleptic drug therapy, treated by bilateral eminectomy. J Craniomaxillofac Surg. 1996; 24(3):184-8. DOI: 10.1016/s1010-5182(96)80054-0. View

15.

Reneker J, Paz J, Petrosino C, Cook C . Diagnostic accuracy of clinical tests and signs of temporomandibular joint disorders: a systematic review of the literature. J Orthop Sports Phys Ther. 2011; 41(6):408-16. DOI: 10.2519/jospt.2011.3644. View

16.

Cruccu G, Frisardi G, Pauletti G, Romaniello A, Manfredi M . Excitability of the central masticatory pathways in patients with painful temporomandibular disorders. Pain. 1998; 73(3):447-454. DOI: 10.1016/S0304-3959(97)00139-5. View

17.

Marazziti D, Mungai F, Vivarelli L, Presta S, DellOsso B . Pain and psychiatry: a critical analysis and pharmacological review. Clin Pract Epidemiol Ment Health. 2006; 2:31. PMC: 1660535. DOI: 10.1186/1745-0179-2-31. View

18.

Velasco-Ortega E, Monsalve-Guil L, Velasco-Ponferrada C, Medel-Soteras R, Segura-Egea J . Temporomandibular disorders among schizophrenic patients. A case-control study. Med Oral Patol Oral Cir Bucal. 2005; 10(4):315-22. View

19.

Kight M, Gatchel R, Wesley L . Temporomandibular disorders: evidence for significant overlap with psychopathology. Health Psychol. 1999; 18(2):177-82. DOI: 10.1037//0278-6133.18.2.177. View

20.

Bonnot O, Anderson G, Cohen D, Willer J, Tordjman S . Are patients with schizophrenia insensitive to pain? A reconsideration of the question. Clin J Pain. 2009; 25(3):244-52. DOI: 10.1097/AJP.0b013e318192be97. View