Effects of Intermittent Aerobic Training on Passive Avoidance Test (shuttle Box) and Stress Markers in the Dorsal Hippocampus of Wistar Rats Exposed to Administration of Homocysteine

Overview

Journal Iran J Psychiatry Behav Sci

Publisher Brieflands

Specialty Social Sciences

Date 2014 Mar 20

PMID 24644498

Citations 5

Authors

Somayeh Hosseinzadeh

Valiollah Dabidi Roshan

Mehdi Pourasghar

Affiliations

Soon will be listed here.

Abstract

Objective: Elevated amino acid homocysteine (Hcy) levels and insufficient physical activity are the risk factors in Alzheimer disease (AD) development. The effect of intermittent aerobic training on memory retention test and Thiobarbituric Acid Reactive Substances (TBARS) and superoxide dismutase (SOD) levels in the dorsal hippocampus of rats which were stimulated with Hcy is investigated.

Methods: In order to determine the dose at which using Shuttle Box Test recognizes degenerative changes and/or memory impairment, 40 rats were injected by different dosages of Hcy to the dorsal hippocampus. It was observed that the required Hcy dose is 0.6 M. Then 44 rats were divided into four groups including training and control groups at 4 weeks of aerobic exercise in training and control groups at 8 weeks. To determine the effect of homocysteine on the memory impairment, Shuttle Box Test was used on treadmill (5 sessions/week, 12-18 m/min and 10-58.5 min).

Results: Hcy administration caused memory impairment and significant increase in TBARS. Significant decrease in TBARS level was noted after 8 weeks of aerobic exercise, but not after just 4 weeks of exercise compared with control group. In addition, performing 8 weeks of aerobic training led to significantly increased superoxide dismutase (SOD) level and the time of avoidance learning test.

Conclusion: Hyperhomocysteinemia caused learning and memory deficits probably by generating reactive oxygen species (ROS) and the present study showed that regular moderate intensity intermittent exercise may reverse this process and exercise is recommended as a strategy to improve symptoms of senile neurodegenerative disease .

Declaration Of Interest: None.

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References

Naylor A, Persson A, Eriksson P, Jonsdottir I, Thorlin T . Extended voluntary running inhibits exercise-induced adult hippocampal progenitor proliferation in the spontaneously hypertensive rat. J Neurophysiol. 2004; 93(5):2406-14. DOI: 10.1152/jn.01085.2004. View

Ravaglia G, Forti P, Lucicesare A, Pisacane N, Rietti E, Bianchin M . Physical activity and dementia risk in the elderly: findings from a prospective Italian study. Neurology. 2007; 70(19 Pt 2):1786-94. DOI: 10.1212/01.wnl.0000296276.50595.86. View

Lange-Asschenfeldt C, Kojda G . Alzheimer's disease, cerebrovascular dysfunction and the benefits of exercise: from vessels to neurons. Exp Gerontol. 2008; 43(6):499-504. DOI: 10.1016/j.exger.2008.04.002. View

Algaidi S, Christie L, Jenkinson A, Whalley L, Riedel G, Platt B . Long-term homocysteine exposure induces alterations in spatial learning, hippocampal signalling and synaptic plasticity. Exp Neurol. 2005; 197(1):8-21. DOI: 10.1016/j.expneurol.2005.07.003. View

Eggermont L, Swaab D, Luiten P, Scherder E . Exercise, cognition and Alzheimer's disease: more is not necessarily better. Neurosci Biobehav Rev. 2005; 30(4):562-75. DOI: 10.1016/j.neubiorev.2005.10.004. View

Kramer A, Erickson K, Colcombe S . Exercise, cognition, and the aging brain. J Appl Physiol (1985). 2006; 101(4):1237-42. DOI: 10.1152/japplphysiol.00500.2006. View

Podewils L, Guallar E, Kuller L, Fried L, Lopez O, Carlson M . Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study. Am J Epidemiol. 2005; 161(7):639-51. DOI: 10.1093/aje/kwi092. View

van den Kommer T, Dik M, Comijs H, Jonker C, Deeg D . Homocysteine and inflammation: predictors of cognitive decline in older persons?. Neurobiol Aging. 2008; 31(10):1700-9. DOI: 10.1016/j.neurobiolaging.2008.09.009. View

Kidd P . Alzheimer's disease, amnestic mild cognitive impairment, and age-associated memory impairment: current understanding and progress toward integrative prevention. Altern Med Rev. 2008; 13(2):85-115. View

10.

Zylberstein D, Lissner L, Bjorkelund C, Mehlig K, Thelle D, Gustafson D . Midlife homocysteine and late-life dementia in women. A prospective population study. Neurobiol Aging. 2009; 32(3):380-6. DOI: 10.1016/j.neurobiolaging.2009.02.024. View

11.

Santiard-Baron D, Aupetit J, Janel N . Plasma homocysteine levels are not increased in murine models of Alzheimer's disease. Neurosci Res. 2005; 53(4):447-9. DOI: 10.1016/j.neures.2005.09.001. View

12.

Massoud F, Belleville S, Bergman H, Kirk J, Chertkow H, Nasreddine Z . Mild cognitive impairment and cognitive impairment, no dementia: Part B, therapy. Alzheimers Dement. 2009; 3(4):283-91. DOI: 10.1016/j.jalz.2007.07.002. View

13.

Heyn P, Abreu B, Ottenbacher K . The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis. Arch Phys Med Rehabil. 2004; 85(10):1694-704. DOI: 10.1016/j.apmr.2004.03.019. View

14.

Ravaglia G, Forti P, Maioli F, Chiappelli M, Montesi F, Tumini E . Blood inflammatory markers and risk of dementia: The Conselice Study of Brain Aging. Neurobiol Aging. 2006; 28(12):1810-20. DOI: 10.1016/j.neurobiolaging.2006.08.012. View

15.

Cascalheira J, Joao S, Pinhancos S, Castro R, Palmeira M, Almeida S . Serum homocysteine: interplay with other circulating and genetic factors in association to Alzheimer's type dementia. Clin Biochem. 2009; 42(9):783-90. DOI: 10.1016/j.clinbiochem.2009.02.006. View

16.

Miller J . Homocysteine, Alzheimer's disease, and cognitive function. Nutrition. 2000; 16(7-8):675-7. DOI: 10.1016/s0899-9007(00)00307-5. View

17.

Jin Y, Brennan L . Effects of homocysteine on metabolic pathways in cultured astrocytes. Neurochem Int. 2008; 52(8):1410-5. DOI: 10.1016/j.neuint.2008.03.001. View

18.

Cotman C, Berchtold N, Christie L . Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci. 2007; 30(9):464-72. DOI: 10.1016/j.tins.2007.06.011. View

19.

Baydas G, Ozer M, Yasar A, Tuzcu M, Koz S . Melatonin improves learning and memory performances impaired by hyperhomocysteinemia in rats. Brain Res. 2005; 1046(1-2):187-94. DOI: 10.1016/j.brainres.2005.04.011. View

20.

van Praag H . Neurogenesis and exercise: past and future directions. Neuromolecular Med. 2008; 10(2):128-40. DOI: 10.1007/s12017-008-8028-z. View