Characterization of a Full-length Infectious Clone of Bovine Foamy Virus 3026

Overview

Journal Virol Sin

Specialty Microbiology

Date 2014 Mar 20

PMID 24643936

Citations 10

Authors

Tiejun Bing

Hong Yu

Yue Li

Lei Sun

Juan Tan

Yunqi Geng

Wentao Qiao

Affiliations

Soon will be listed here.

Abstract

The biological features of most foamy viruses (FVs) are poorly understood, including bovine foamy virus (BFV). BFV strain 3026 (BFV3026) was isolated from the peripheral blood mononuclear cells of an infected cow in Zhangjiakou, China. A full-length genomic clone of BFV3026 was obtained from BFV3026-infected cells, and it exhibited more than 99% amino acid (AA) homology to another BFV strain isolated in the USA. Upon transfection into fetal canine thymus cells, the full-length BFV3026 clone produced viral structural and auxiliary proteins, typical cytopathic effects, and virus particles. These results demonstrate that the full-length BFV3026 clone is fully infectious and can be used in further BFV3026 research.

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