Presentation of an Immunodominant T-cell Epitope of Hepatitis B Surface Antigen by the HLA-DPw4 Molecule

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1989 Feb 1

PMID 2463381

Citations 13

Authors

E Celis

R W Karr

Affiliations

Soon will be listed here.

Abstract

Human T cells that recognize a major epitope of the hepatitis B surface antigen were studied for their ability to react with antigen when presented by mouse fibroblasts that express class II products of the human major histocompatibility gene complex after gene transfection. L cells expressing HLA-DPw4, but not those expressing HLA-DR4 or HLA-DR7, induced strong proliferative responses of antigen-specific T cells to either hepatitis B surface antigen or the synthetic peptide S1d, which bears the immunodominant T-cell epitope. These results identified a genetic restriction element of human helper T-lymphocyte responses to a major antigenic determinant of hepatitis B virus and might be important in the design of subunit vaccines to this pathogen. Peptides that induce T-cell responses that are restricted by a frequently encountered major histocompatibility complex molecule in the general population such as DPw4 would be ideal candidates as subunit vaccines.

Citing Articles

T cell repertoire to citrullinated self-peptides in healthy humans is not confined to the HLA-DR SE alleles; Targeting of citrullinated self-peptides presented by HLA-DP4 for tumour therapy.

Brentville V, Symonds P, Cook K, Daniels I, Pitt T, Gijon M Oncoimmunology. 2019; 8(5):e1576490.

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Development of a humanized HLA-A2.1/DP4 transgenic mouse model and the use of this model to map HLA-DP4-restricted epitopes of HBV envelope protein.

Ru Z, Xiao W, Pajot A, Kou Z, Sun S, Maillere B PLoS One. 2012; 7(3):e32247.

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HLA-associated susceptibility to childhood B-cell precursor ALL: definition and role of HLA-DPB1 supertypes.

Taylor G, Hussain A, Lightfoot T, Birch J, Eden T, Greaves M Br J Cancer. 2008; 98(6):1125-31.

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Partial delipidation improves the T-cell antigenicity of hepatitis B virus surface antigen.

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Non-responsiveness to hepatitis B surface antigen vaccines is not caused by defective antigen presentation or a lack of B7 co-stimulation.

Desombere I, Cao T, Gijbels Y, Leroux-Roels G Clin Exp Immunol. 2005; 140(1):126-37.

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