Is the Interleukin 8 Promoter Polymorphism Rs4073/-251T >A Associated with Clostridium Difficile Infection?

Overview

Journal Clin Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2014 Mar 18

PMID 24633688

Citations 4

Authors

Fabio Miyajima

Andrew Swale

J Eunice Zhang

Ana Alfirevic

Margaret Little

Nicholas J Beeching

Godfrey Smith

Ruwanthi Kolamunnage-Dona

Munir Pirmohamed

Affiliations

Soon will be listed here.

Abstract

The interleukin 8 gene single-nucleotide polymorphism rs4073/-251T >A predisposes to Clostridium difficile infection (CDI), but this association has not been independently validated. In this study, we were unable to replicate this association in either a white cohort or by meta-analysis, suggesting that rs4073/-251T >A is unlikely to constitute a major risk factor for CDI.

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