Nicotine Blood Levels and Short-term Smoking Reduction with an Electronic Nicotine Delivery System

Overview

Journal Am J Health Behav

Date 2014 Mar 18

PMID 24629555

Citations 59

Authors

Mitchell A Nides

Scott J Leischow

Meghna Bhatter

Michael Simmons

Affiliations

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Abstract

Objectives: To evaluate nicotine delivery from the NJOY® King Bold Electronic Nicotine Delivery System (ENDS) and its short-term potential for smoking reduction or cessation.

Methods: One week of ad libitum use was followed by measurements of plasma nicotine, heart rate, and craving and withdrawal after 12 hours of nicotine abstinence in 25 adult smokers not interested in quitting.

Results: After 5 minutes of use, blood nicotine levels increased by a mean of 3.5 ng/mL (p < .001), heart rate increased, and craving was reduced by 55%. Cigarettes per day were reduced by 39% during the test week, and perceptions of use for reduction or cessation were positive.

Conclusions: The NJOY® King Bold ENDS delivers nicotine and led to short-term smoking reduction.

Citing Articles

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The Hidden Dangers: E-Cigarettes, Heated Tobacco, and Their Impact on Oxidative Stress and Atherosclerosis-A Systematic Review and Narrative Synthesis of the Evidence.

Magna A, Polisena N, Polisena L, Bagnato C, Pacella E, Carnevale R Antioxidants (Basel). 2024; 13(11).

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The potential of new nicotine and tobacco products as tools for people who smoke to quit combustible cigarettes - a systematic review of common practices and guidance towards a robust study protocol to measure cessation efficacy.

Pluym N, Burkhardt T, Scherer G, Scherer M Harm Reduct J. 2024; 21(1):130.

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Electronic cigarettes for smoking cessation.

Lindson N, Butler A, McRobbie H, Bullen C, Hajek P, Begh R Cochrane Database Syst Rev. 2024; 1:CD010216.

PMID: 38189560 PMC: 10772980. DOI: 10.1002/14651858.CD010216.pub8.

Effects of Device Settings and E-Liquid Characteristics on Mouth-Throat Losses of Nicotine Delivered with Electronic Nicotine Delivery Systems (ENDS).

Hosseini S, Gholap V, Halquist M, Golshahi L J Aerosol Sci. 2023; 171.

PMID: 37092025 PMC: 10121190. DOI: 10.1016/j.jaerosci.2023.106178.