Oxidative Stress and Schizophrenia: Recent Breakthroughs from an Old Story

Overview

Journal Curr Opin Psychiatry

Specialty Psychiatry

Date 2014 Mar 12

PMID 24613987

Citations 74

Authors

Francesco E Emiliani

Thomas W Sedlak

Akira Sawa

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: Oxidative stress has become an exciting area of schizophrenia research, and provides ample opportunities and hope for a better understanding of its pathophysiology, which may lead to novel treatment strategies. This review describes how recent methodological advances have allowed the study of oxidative stress to tackle fundamental questions and have provided several conceptual breakthroughs to the field.

Recent Findings: Recent human studies support the notion that intrinsic susceptibility to oxidative stress may underlie the pathophysiology of schizophrenia. More than one animal model that may be relevant to study the biology of schizophrenia also shows sign of oxidative stress in the brain.

Summary: These advances have made this topic of paramount importance to the understanding of schizophrenia and will play a role in advancing the treatment options. This review covers topics from the classic biochemical studies of human biospecimens to the use of magnetic resonance spectroscopy and novel mouse models, and focuses on highlighting the promising areas of research.

Citing Articles

Progress in the study of oxidative stress damage in patients with schizophrenia: challenges and opportunities.

Zhang K, Zou L, Cai Y Front Psychiatry. 2025; 16:1505397.

PMID: 40060748 PMC: 11885282. DOI: 10.3389/fpsyt.2025.1505397.

Variations to plasma HO levels and TAC in chronical medicated and treatment-resistant male schizophrenia patients: Correlations with psychopathology.

Yang H, Sun W, Yang M, Li J, Zhang J, Zhang X Schizophrenia (Heidelb). 2024; 10(1):45.

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Antioxidant Chimeric Molecules: Are Chemical Motifs Additive? The Case of a Selenium-Based Ligand.

Zeppilli D, Aldinio-Colbachini A, Ribaudo G, Tubaro C, Dalla Tiezza M, Bortoli M Int J Mol Sci. 2023; 24(14).

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Insights into the role of intracellular calcium signaling in the neurobiology of neurodevelopmental disorders.

Klocke B, Krone K, Tornes J, Moore C, Ott H, Pitychoutis P Front Neurosci. 2023; 17:1093099.

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Radical Scavenging Potential of Ginkgolides and Bilobalide: Insight from Molecular Modeling.

Zeppilli D, Ribaudo G, Pompermaier N, Madabeni A, Bortoli M, Orian L Antioxidants (Basel). 2023; 12(2).

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