17β-Estradiol Alters Rat Type-II Alveolar Cell Recovery from High Levels of Ozone

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Mar 7

PMID 24599035

Citations 6

Authors

Madeleine Chalfant

Karen K Bernd

Affiliations

Soon will be listed here.

Abstract

Respiratory health is negatively impacted by exposure to ozone or to estrogens. Increasingly, individuals have simultaneous environmental exposure to both compounds. Characterizing the cellular responses stimulated by the combination of ozone and estrogens, therefore, is crucial to our complete understanding of the compounds' environmental health impacts. Our work introduces an alveolar cell culture model with defined media that provides evidence of ozone damage and determines sex hormones alter the cells' susceptibility to oxidative damage. Specifically, we investigated the individual and combined effects of environmentally relevant levels of ozone and 17β-estradiol on non-cancerous rat, type-II alveolar cells by examining biomarkers of cellular health and redox balance. The data reveal a complex role for 17β-estradiol in cellular recovery from 1 hr exposure to high ozone levels. At 0.5 hr post-ozone necrosis and inflammation markers show 17β-estradiol augments the detrimental effects of 350 ppb ozone, but after 24 hr of recovery, steroid treatment alters glutathione redox ratio and allows cellular proliferation.

Citing Articles

Analyzing EEG patterns in young adults exposed to different acrophobia levels: a VR study.

Russo S, Tibermacine I, Tibermacine A, Chebana D, Nahili A, Starczewscki J Front Hum Neurosci. 2024; 18:1348154.

PMID: 38770396 PMC: 11102978. DOI: 10.3389/fnhum.2024.1348154.

17β-Estradiol affects lung function and inflammation following ozone exposure in a sex-specific manner.

Fuentes N, Nicoleau M, Cabello N, Montes D, Zomorodi N, Chroneos Z Am J Physiol Lung Cell Mol Physiol. 2019; 317(5):L702-L716.

PMID: 31553636 PMC: 6879909. DOI: 10.1152/ajplung.00176.2019.

Contributions of charcoal, tobacco, and syrup to the toxicity and particle distribution of waterpipe tobacco smoke.

Bernd K, DeGrood D, Stadtler H, Coats S, Carmack D, Mailig R Toxicol Lett. 2019; 313:60-65.

PMID: 31226396 PMC: 6687299. DOI: 10.1016/j.toxlet.2019.06.003.

Effect of acute ozone exposure on the lung metabolomes of obese and lean mice.

Mathews J, Kasahara D, Cho Y, Bell L, Gunst P, Karoly E PLoS One. 2017; 12(7):e0181017.

PMID: 28704544 PMC: 5509247. DOI: 10.1371/journal.pone.0181017.

Improved hematopoietic differentiation of human pluripotent stem cells via estrogen receptor signaling pathway.

Kim H, Lee J, Heo H, Yang S, Ha K, Park W Cell Biosci. 2016; 6(1):50.

PMID: 27583127 PMC: 5006567. DOI: 10.1186/s13578-016-0111-9.

References

Lin P, Chang Y, Chen C, Yang W, Cheng Y, Chang L . A comparative study on the effects of 2,3,7,8,-tetrachlorodibenzo-p-dioxin polychlorinated biphenyl126 and estrogen in human bronchial epithelial cells. Toxicol Appl Pharmacol. 2004; 195(1):83-91. DOI: 10.1016/j.taap.2003.11.001. View

van de Wetering J, van Golde L, Batenburg J . Collectins: players of the innate immune system. Eur J Biochem. 2004; 271(7):1229-49. DOI: 10.1111/j.1432-1033.2004.04040.x. View

Chang L, Chang Y, Ho C, Tsai M, Lin P . Increase of carcinogenic risk via enhancement of cyclooxygenase-2 expression and hydroxyestradiol accumulation in human lung cells as a result of interaction between BaP and 17-beta estradiol. Carcinogenesis. 2007; 28(7):1606-12. DOI: 10.1093/carcin/bgm013. View

Karlsson C, Helenius G, Fernandes O, Karlsson M . Oestrogen receptor β in NSCLC - prevalence, proliferative influence, prognostic impact and smoking. APMIS. 2012; 120(6):451-8. DOI: 10.1111/j.1600-0463.2011.02850.x. View

Miyaguchi C, Muranaka S, Kanno T, Fujita H, Akiyama J, Yoshioka T . 17beta-estradiol suppresses ROS-induced apoptosis of CHO cells through inhibition of lipid peroxidation-coupled membrane permeability transition. Physiol Chem Phys Med NMR. 2005; 36(1):21-35. View

Wang G, Umstead T, Phelps D, Al-Mondhiry H, Floros J . The effect of ozone exposure on the ability of human surfactant protein a variants to stimulate cytokine production. Environ Health Perspect. 2002; 110(1):79-84. PMC: 1240696. DOI: 10.1289/ehp.0211079. View

Welshons W, Wolf M, Murphy C, Jordan V . Estrogenic activity of phenol red. Mol Cell Endocrinol. 1988; 57(3):169-78. DOI: 10.1016/0303-7207(88)90072-x. View

Diamanti-Kandarakis E, Bourguignon J, Giudice L, Hauser R, Prins G, Soto A . Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocr Rev. 2009; 30(4):293-342. PMC: 2726844. DOI: 10.1210/er.2009-0002. View

Medina-Ramon M, Zanobetti A, Schwartz J . The effect of ozone and PM10 on hospital admissions for pneumonia and chronic obstructive pulmonary disease: a national multicity study. Am J Epidemiol. 2006; 163(6):579-88. DOI: 10.1093/aje/kwj078. View

10.

Ho C, Ling Y, Chang L, Tsai H, Tsai M, Lin P . 17-Beta estradiol and hydroxyestradiols interact via the NF-kappa B pathway to elevate cyclooxygenase 2 expression and prostaglandin E2 secretion in human bronchial epithelial cells. Toxicol Sci. 2008; 104(2):294-302. DOI: 10.1093/toxsci/kfn096. View

11.

de Torres J, Cote C, Lopez M, Casanova C, Diaz O, Marin J . Sex differences in mortality in patients with COPD. Eur Respir J. 2008; 33(3):528-35. DOI: 10.1183/09031936.00096108. View

12.

Hamilton K, Mbai F, Gupta S, Knowlton A . Estrogen, heat shock proteins, and NFkappaB in human vascular endothelium. Arterioscler Thromb Vasc Biol. 2004; 24(9):1628-33. DOI: 10.1161/01.ATV.0000137188.76195.fb. View

13.

Klaunig J, Kamendulis L, Hocevar B . Oxidative stress and oxidative damage in carcinogenesis. Toxicol Pathol. 2009; 38(1):96-109. DOI: 10.1177/0192623309356453. View

14.

Dougherty S, Mazhawidza W, Bohn A, Robinson K, Mattingly K, Blankenship K . Gender difference in the activity but not expression of estrogen receptors alpha and beta in human lung adenocarcinoma cells. Endocr Relat Cancer. 2006; 13(1):113-34. PMC: 1472635. DOI: 10.1677/erc.1.01118. View

15.

Roy D, Cai Q, Felty Q, Narayan S . Estrogen-induced generation of reactive oxygen and nitrogen species, gene damage, and estrogen-dependent cancers. J Toxicol Environ Health B Crit Rev. 2007; 10(4):235-57. DOI: 10.1080/15287390600974924. View

16.

Bjornstrom L, Sjoberg M . Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes. Mol Endocrinol. 2005; 19(4):833-42. DOI: 10.1210/me.2004-0486. View

17.

Sindhu R, Mitsuhashi M, Kikkawa Y . Induction of cytochrome P-450 1A2 by oxidized tryptophan in Hepa lclc7 cells. J Pharmacol Exp Ther. 2000; 292(3):1008-14. View

18.

Zhang Y, Champagne N, Beitel L, Goodyer C, Trifiro M, Leblanc A . Estrogen and androgen protection of human neurons against intracellular amyloid beta1-42 toxicity through heat shock protein 70. J Neurosci. 2004; 24(23):5315-21. PMC: 6729301. DOI: 10.1523/JNEUROSCI.0913-04.2004. View

19.

Sindhu , Kikkawa . Superinduction of Oxidized Tryptophan-Inducible Cytochrome P450 1A1 by Cycloheximide in Hepa lclc7 Cells. In Vitr Mol Toxicol. 2000; 12(3):149-162. View

20.

Greenhough A, Smartt H, Moore A, Roberts H, Williams A, Paraskeva C . The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. Carcinogenesis. 2009; 30(3):377-86. DOI: 10.1093/carcin/bgp014. View