A Gradual Increase of Iron Toward the Medial-inferior Tip of the Subthalamic Nucleus

Overview

Journal Hum Brain Mapp

Publisher Wiley

Specialty Neurology

Date 2014 Mar 6

PMID 24596026

Citations 20

Authors

Gilles de Hollander

Max C Keuken

Pierre-Louis Bazin

Marcel Weiss

Jane Neumann

Katja Reimann

Miriam Wahnert

Robert Turner

Birte U Forstmann

Andreas Schafer

Affiliations

Soon will be listed here.

Abstract

The subthalamic nucleus (STN) is an important node of the cortico-basal ganglia network and the main target of deep brain stimulation (DBS) in Parkinson's disease. Histological studies have revealed an inhomogeneous iron distribution within the STN, which has been related to putative subdivisions within this nucleus. Here, we investigate the iron distribution in more detail using quantitative susceptibility mapping (QSM), a novel magnetic resonance imaging (MRI) contrast mechanism. QSM allows for detailed assessment of iron content in both in vivo and postmortem tissue. Twelve human participants and 7 postmortem brain samples containing the STN were scanned using ultra-high field 7 Tesla (T) MRI. Iron concentrations were found to be higher in the medial-inferior tip of the STN. Using quantitative methods we show that the increase of iron concentration towards the medial-inferior tip is of a gradual rather than a discrete nature.

Citing Articles

Bilgic B, Costagli M, Chan K, Duyn J, Langkammer C, Lee J Magn Reson Med. 2024; 91(5):1834-1862.

PMID: 38247051 PMC: 10950544. DOI: 10.1002/mrm.30006.

QSM Throughout the Body.

Dimov A, Li J, Nguyen T, Roberts A, Spincemaille P, Straub S J Magn Reson Imaging. 2023; 57(6):1621-1640.

PMID: 36748806 PMC: 10192074. DOI: 10.1002/jmri.28624.

Neuroimaging at 7 Tesla: a pictorial narrative review.

Okada T, Fujimoto K, Fushimi Y, Akasaka T, Thuy D, Shima A Quant Imaging Med Surg. 2022; 12(6):3406-3435.

PMID: 35655840 PMC: 9131333. DOI: 10.21037/qims-21-969.

Visualization of iron-rich subcortical structures in non-human primates in vivo by quantitative susceptibility mapping at 3T MRI.

Yoshida A, Ye F, Yu D, Leopold D, Hikosaka O Neuroimage. 2021; 241:118429.

PMID: 34311068 PMC: 11479656. DOI: 10.1016/j.neuroimage.2021.118429.

Iron distribution in the lentiform nucleus: A post-mortem MRI and histology study.

De Barros A, Arribarat G, Lotterie J, Dominguez G, Chaynes P, Peran P Brain Struct Funct. 2021; 226(2):351-364.

PMID: 33389044 DOI: 10.1007/s00429-020-02175-7.

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