Estrogen Regulates the Tumour Suppressor MiRNA-30c and Its Target Gene, MTA-1, in Endometrial Cancer

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Mar 6

PMID 24595016

Citations 31

Authors

Xiangyi Kong

Xiaofeng Xu

Yuhua Yan

Feifei Guo

Jian Li

Yali Hu

Huaijun Zhou

Qingying Xun

Affiliations

Soon will be listed here.

Abstract

MicroRNA-30c (miR-30c) has been reported to be a tumour suppressor in endometrial cancer (EC). We demonstrate that miR-30c is down-regulated in EC tissue and is highly expressed in estrogen receptor (ER)-negative HEC-1-B cells. MiR-30c directly inhibits MTA-1 expression and functions as a tumour suppressor via the miR-30c-MTA-1 signalling pathway. Furthermore, miR-30c is decreased upon E2 treatment in both ER-positive Ishikawa and ER-negative HEC-1-B cells. Taken together, our results suggest that miR-30c is an important deregulated miRNA in EC and might serve as a potential biomarker and novel therapeutic target for EC.

Citing Articles

Expression Profiles of Estrogen-Regulated MicroRNAs in Cancer Cells.

Archer A, Kutter C, Williams C Methods Mol Biol. 2022; 2418:313-343.

PMID: 35119673 DOI: 10.1007/978-1-0716-1920-9_18.

Long non-coding RNA NNT-AS1 positively regulates NPM1 expression to affect the proliferation of estrogen-mediated endometrial carcinoma by interacting.

Shen J, Yuan Z, Sheng J, Feng X, Wang H, Wang Y J Cancer. 2022; 13(1):112-123.

PMID: 34976175 PMC: 8692688. DOI: 10.7150/jca.62630.

The Central Roles of Noncoding RNA in Estrogen-Dependent Female Reproductive System Tumors.

Tu J, Yang H, Jiang L, Chen Y, Li Z, Li L Int J Endocrinol. 2021; 2021:5572063.

PMID: 34122542 PMC: 8169271. DOI: 10.1155/2021/5572063.

Association of and SNPs with Bladder Cancer Risk in North Indian Population: A Pilot Study.

Verma A, Mittal R Indian J Clin Biochem. 2021; 36(2):194-199.

PMID: 33867710 PMC: 7994493. DOI: 10.1007/s12291-020-00881-x.

Non-Coding RNAs as Prognostic Markers for Endometrial Cancer.

Piergentili R, Zaami S, Cavaliere A, Signore F, Scambia G, Mattei A Int J Mol Sci. 2021; 22(6).

PMID: 33808791 PMC: 8003471. DOI: 10.3390/ijms22063151.

References

Guo J, Dong Q, Fang Z, Chen X, Lu H, Wang K . Identification of miRNAs that are associated with tumor metastasis in neuroblastoma. Cancer Biol Ther. 2010; 9(6):446-52. DOI: 10.4161/cbt.9.6.10894. View

Goparaju C, Blasberg J, Volinia S, Palatini J, Ivanov S, Donington J . Onconase mediated NFKβ downregulation in malignant pleural mesothelioma. Oncogene. 2011; 30(24):2767-77. PMC: 3118086. DOI: 10.1038/onc.2010.643. View

Klinge C . miRNAs and estrogen action. Trends Endocrinol Metab. 2012; 23(5):223-33. PMC: 3348384. DOI: 10.1016/j.tem.2012.03.002. View

Wickramasinghe N, Manavalan T, Dougherty S, Riggs K, Li Y, Klinge C . Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells. Nucleic Acids Res. 2009; 37(8):2584-95. PMC: 2677875. DOI: 10.1093/nar/gkp117. View

Masuda M, Miki Y, Hata S, Takagi K, Sakurai M, Ono K . An induction of microRNA, miR-7 through estrogen treatment in breast carcinoma. J Transl Med. 2012; 10 Suppl 1:S2. PMC: 3445861. DOI: 10.1186/1479-5876-10-s1-s2. View

Balasenthil S, Broaddus R, Kumar R . Expression of metastasis-associated protein 1 (MTA1) in benign endometrium and endometrial adenocarcinomas. Hum Pathol. 2006; 37(6):656-61. DOI: 10.1016/j.humpath.2006.01.024. View

Duisters R, Tijsen A, Schroen B, Leenders J, Lentink V, van der Made I . miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling. Circ Res. 2008; 104(2):170-8, 6p following 178. DOI: 10.1161/CIRCRESAHA.108.182535. View

Yamagata K, Fujiyama S, Ito S, Ueda T, Murata T, Naitou M . Maturation of microRNA is hormonally regulated by a nuclear receptor. Mol Cell. 2009; 36(2):340-7. DOI: 10.1016/j.molcel.2009.08.017. View

Da Sacco L, Masotti A . Recent insights and novel bioinformatics tools to understand the role of microRNAs binding to 5' untranslated region. Int J Mol Sci. 2012; 14(1):480-95. PMC: 3565276. DOI: 10.3390/ijms14010480. View

10.

Zhou H, Xu X, Xun Q, Yu D, Ling J, Guo F . microRNA-30c negatively regulates endometrial cancer cells by targeting metastasis-associated gene-1. Oncol Rep. 2011; 27(3):807-12. DOI: 10.3892/or.2011.1574. View

11.

Tanic M, Yanowsky K, Rodriguez-Antona C, Andres R, Marquez-Rodas I, Osorio A . Deregulated miRNAs in hereditary breast cancer revealed a role for miR-30c in regulating KRAS oncogene. PLoS One. 2012; 7(6):e38847. PMC: 3372467. DOI: 10.1371/journal.pone.0038847. View

12.

Garofalo M, Romano G, Di Leva G, Nuovo G, Jeon Y, Ngankeu A . EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers. Nat Med. 2011; 18(1):74-82. PMC: 3467100. DOI: 10.1038/nm.2577. View

13.

Busacca S, Germano S, De Cecco L, Rinaldi M, Comoglio F, Favero F . MicroRNA signature of malignant mesothelioma with potential diagnostic and prognostic implications. Am J Respir Cell Mol Biol. 2009; 42(3):312-9. DOI: 10.1165/rcmb.2009-0060OC. View

14.

Chen X, Yan Q, Li S, Zhou L, Yang H, Yang Y . Expression of the tumor suppressor miR-206 is associated with cellular proliferative inhibition and impairs invasion in ERα-positive endometrioid adenocarcinoma. Cancer Lett. 2011; 314(1):41-53. DOI: 10.1016/j.canlet.2011.09.014. View

15.

Joglekar M, Patil D, Joglekar V, Rao G, Reddy D, Mitnala S . The miR-30 family microRNAs confer epithelial phenotype to human pancreatic cells. Islets. 2010; 1(2):137-47. DOI: 10.4161/isl.1.2.9578. View

16.

Li J, Donath S, Li Y, Qin D, Prabhakar B, Li P . miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway. PLoS Genet. 2010; 6(1):e1000795. PMC: 2793031. DOI: 10.1371/journal.pgen.1000795. View

17.

Kloosterman W, Plasterk R . The diverse functions of microRNAs in animal development and disease. Dev Cell. 2006; 11(4):441-50. DOI: 10.1016/j.devcel.2006.09.009. View

18.

Patel N, Tahara S, Malik P, Kalra V . Involvement of miR-30c and miR-301a in immediate induction of plasminogen activator inhibitor-1 by placental growth factor in human pulmonary endothelial cells. Biochem J. 2010; 434(3):473-82. PMC: 3078570. DOI: 10.1042/BJ20101585. View

19.

Bhat-Nakshatri P, Wang G, Collins N, Thomson M, Geistlinger T, Carroll J . Estradiol-regulated microRNAs control estradiol response in breast cancer cells. Nucleic Acids Res. 2009; 37(14):4850-61. PMC: 2724297. DOI: 10.1093/nar/gkp500. View

20.

Du B, Yang Z, Zhong X, Fang M, Yan Y, Qi G . Metastasis-associated protein 1 induces VEGF-C and facilitates lymphangiogenesis in colorectal cancer. World J Gastroenterol. 2011; 17(9):1219-26. PMC: 3063917. DOI: 10.3748/wjg.v17.i9.1219. View