Identification of Amino Acids Relevant to Three Antigenic Determinants on the Fusion Protein of Newcastle Disease Virus That Are Involved in Fusion Inhibition and Neutralization

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1988 Nov 1

PMID 2459417

Citations 38

Authors

T Toyoda

B Gotoh

T Sakaguchi

H Kida

Y Nagai

Affiliations

Soon will be listed here.

Abstract

Nucleotide sequence analysis of F protein antigenic variants of Newcastle disease virus mapped three distinct antigenic determinants to positions 343, 72, and 161 on the protein. The high fusion-inhibiting and neutralizing capacities of all of the monoclonal antibodies used for selection suggested close functional and structural relationships of the three positions with the fusion-inducing N-terminal region of the F1 subunit. The former two positions were located at the cysteine cluster domain near the C terminus of the F1 subunit and at the major hydrophilic domain in the F2 subunit, respectively, and both domains appeared to represent the major antigenic determinants of paramyxovirus F protein.

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References

Barrett T, Clarke D, Evans S, Rima B . The nucleotide sequence of the gene encoding the F protein of canine distemper virus: a comparison of the deduced amino acid sequence with other paramyxoviruses. Virus Res. 1987; 8(4):373-86. DOI: 10.1016/0168-1702(87)90009-8. View

Waxham M, Server A, Goodman H, Wolinsky J . Cloning and sequencing of the mumps virus fusion protein gene. Virology. 1987; 159(2):381-8. DOI: 10.1016/0042-6822(87)90477-6. View

Millar N, Chambers P, Emmerson P . Nucleotide sequence of the fusion and haemagglutinin-neuraminidase glycoprotein genes of Newcastle disease virus, strain Ulster: molecular basis for variations in pathogenicity between strains. J Gen Virol. 1988; 69 ( Pt 3):613-20. DOI: 10.1099/0022-1317-69-3-613. View

Tsukiyama K, Yoshikawa Y, Yamanouchi K . Fusion glycoprotein (F) of rinderpest virus: entire nucleotide sequence of the F mRNA, and several features of the F protein. Virology. 1988; 164(2):523-30. DOI: 10.1016/0042-6822(88)90567-3. View

Homma M, Ouchi M . Trypsin action on the growth of Sendai virus in tissue culture cells. 3. Structural difference of Sendai viruses grown in eggs and tissue culture cells. J Virol. 1973; 12(6):1457-65. PMC: 356788. DOI: 10.1128/JVI.12.6.1457-1465.1973. View

Scheid A, Choppin P . Identification of biological activities of paramyxovirus glycoproteins. Activation of cell fusion, hemolysis, and infectivity of proteolytic cleavage of an inactive precursor protein of Sendai virus. Virology. 1974; 57(2):475-90. DOI: 10.1016/0042-6822(74)90187-1. View

Nagai Y, Klenk H, Rott R . Proteolytic cleavage of the viral glycoproteins and its significance for the virulence of Newcastle disease virus. Virology. 1976; 72(2):494-508. DOI: 10.1016/0042-6822(76)90178-1. View

Gething M, White J, Waterfield M . Purification of the fusion protein of Sendai virus: analysis of the NH2-terminal sequence generated during precursor activation. Proc Natl Acad Sci U S A. 1978; 75(6):2737-40. PMC: 392638. DOI: 10.1073/pnas.75.6.2737. View

Merz D, Scheid A, Choppin P . Importance of antibodies to the fusion glycoprotein of paramyxoviruses in the prevention of spread of infection. J Exp Med. 1980; 151(2):275-88. PMC: 2185790. DOI: 10.1084/jem.151.2.275. View

10.

Richardson C, Scheid A, Choppin P . Specific inhibition of paramyxovirus and myxovirus replication by oligopeptides with amino acid sequences similar to those at the N-termini of the F1 or HA2 viral polypeptides. Virology. 1980; 105(1):205-22. DOI: 10.1016/0042-6822(80)90168-3. View

11.

Hopp T, Woods K . Prediction of protein antigenic determinants from amino acid sequences. Proc Natl Acad Sci U S A. 1981; 78(6):3824-8. PMC: 319665. DOI: 10.1073/pnas.78.6.3824. View

12.

Nishikawa K, Isomura S, Suzuki S, Watanabe E, Hamaguchi M, Yoshida T . Monoclonal antibodies to the HN glycoprotein of Newcastle disease virus. Biological characterization and use for strain comparisons. Virology. 1983; 130(2):318-30. DOI: 10.1016/0042-6822(83)90086-7. View

13.

PATERSON R, Harris T, Lamb R . Fusion protein of the paramyxovirus simian virus 5: nucleotide sequence of mRNA predicts a highly hydrophobic glycoprotein. Proc Natl Acad Sci U S A. 1984; 81(21):6706-10. PMC: 391999. DOI: 10.1073/pnas.81.21.6706. View

14.

Collins P, Huang Y, Wertz G . Nucleotide sequence of the gene encoding the fusion (F) glycoprotein of human respiratory syncytial virus. Proc Natl Acad Sci U S A. 1984; 81(24):7683-7. PMC: 392216. DOI: 10.1073/pnas.81.24.7683. View

15.

Blumberg B, Giorgi C, Rose K, Kolakofsky D . Sequence determination of the Sendai virus fusion protein gene. J Gen Virol. 1985; 66 ( Pt 2):317-31. DOI: 10.1099/0022-1317-66-2-317. View

16.

Shioda T, Iwasaki K, Shibuta H . Determination of the complete nucleotide sequence of the Sendai virus genome RNA and the predicted amino acid sequences of the F, HN and L proteins. Nucleic Acids Res. 1986; 14(4):1545-63. PMC: 339528. DOI: 10.1093/nar/14.4.1545. View

17.

Spriggs M, Olmsted R, Venkatesan S, Coligan J, Collins P . Fusion glycoprotein of human parainfluenza virus type 3: nucleotide sequence of the gene, direct identification of the cleavage-activation site, and comparison with other paramyxoviruses. Virology. 1986; 152(1):241-51. DOI: 10.1016/0042-6822(86)90388-0. View

18.

Abenes G, Kida H, Yanagawa R . Antigenic mapping and functional analysis of the F protein of Newcastle disease virus using monoclonal antibodies. Arch Virol. 1986; 90(1-2):97-110. DOI: 10.1007/BF01314148. View

19.

Coelingh K, WINTER C, Murphy B, Rice J, Kimball P, Olmsted R . Conserved epitopes on the hemagglutinin-neuraminidase proteins of human and bovine parainfluenza type 3 viruses: nucleotide sequence analysis of variants selected with monoclonal antibodies. J Virol. 1986; 60(1):90-6. PMC: 253905. DOI: 10.1128/JVI.60.1.90-96.1986. View

20.

Air G, Laver W . The molecular basis of antigenic variation in influenza virus. Adv Virus Res. 1986; 31:53-102. DOI: 10.1016/s0065-3527(08)60262-6. View