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Testicular "hyperstimulation" Syndrome: a Case of Functional Gonadotropinoma

Overview
Publisher Wiley
Specialty Endocrinology
Date 2014 Mar 5
PMID 24592337
Citations 5
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Abstract

Gonadotropins secreting pituitary tumors tend to present as sellar mass with hypogonadism. Biologically active LH secretion by these tumors resulting in elevated testosterone is extremely rare. We report a case of a 48-year-old male patient who presented with giant pituitary tumor, elevated testosterone, and elevated levels of gonadotropins. Surgical resection of the tumor resulted in normalization of gonadotropins and fall in serum testosterone to subnormal levels in the postoperative period confirming that the tumor was secreting bioactive luteinizing hormone (LH).

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References
1.
Chamoun R, Layfield L, Couldwell W . Gonadotroph adenoma with secondary hypersecretion of testosterone. World Neurosurg. 2012; 80(6):900.e7-11. DOI: 10.1016/j.wneu.2012.11.069. View

2.
Dahlqvist P, Koskinen L, Brannstrom T, Hagg E . Testicular enlargement in a patient with a FSH-secreting pituitary adenoma. Endocrine. 2010; 37(2):289-93. DOI: 10.1007/s12020-009-9302-z. View

3.
Snyder P . Extensive personal experience: gonadotroph adenomas. J Clin Endocrinol Metab. 1995; 80(4):1059-61. DOI: 10.1210/jcem.80.4.7714066. View

4.
Greenman Y, Stern N . Non-functioning pituitary adenomas. Best Pract Res Clin Endocrinol Metab. 2009; 23(5):625-38. DOI: 10.1016/j.beem.2009.05.005. View

5.
Cooper O, Geller J, Melmed S . Ovarian hyperstimulation syndrome caused by an FSH-secreting pituitary adenoma. Nat Clin Pract Endocrinol Metab. 2008; 4(4):234-8. PMC: 2777809. DOI: 10.1038/ncpendmet0758. View