Multiple Levels of Chemokine Receptor Regulation in the Control of Mouse Natural Killer Cell Development

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2014 Mar 5

PMID 24592263

Citations 7

Authors

Giovanni Bernardini

Giorgia Benigni

Fabrizio Antonangeli

Andrea Ponzetta

Angela Santoni

Affiliations

Soon will be listed here.

Abstract

Chemokines play a fundamental role in lymphocyte development, mainly attributable to the control of the correct localization in the proper microenvironments of cells undergoing maturation. Natural killer (NK) cell development occurs in the bone marrow (BM) where their localization is regulated by the balance of chemokine function in cell retention into tissues and mobilization into circulation. In addition, NK cells from several extra-medullary tissues are phenotypically and functionally different from their circulating counterpart suggesting that maturation can be completed in organs other than BM. Indeed, a role of chemokines in NK cell localization into tissues during homeostatic conditions is also documented. In this review, we summarize the current notion related to the relevance of several chemokine/chemokine receptor axes in NK cell development with a focus on the regulation of their expression and function.

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References

Glodek A, Honczarenko M, Le Y, Campbell J, Silberstein L . Sustained activation of cell adhesion is a differentially regulated process in B lymphopoiesis. J Exp Med. 2003; 197(4):461-73. PMC: 2193869. DOI: 10.1084/jem.20021477. View

Stewart C, Walzer T, Robbins S, Malissen B, Vivier E, Prinz I . Germ-line and rearranged Tcrd transcription distinguish bona fide NK cells and NK-like gammadelta T cells. Eur J Immunol. 2007; 37(6):1442-52. DOI: 10.1002/eji.200737354. View

Luevano M, Madrigal A, Saudemont A . Transcription factors involved in the regulation of natural killer cell development and function: an update. Front Immunol. 2012; 3:319. PMC: 3470934. DOI: 10.3389/fimmu.2012.00319. View

Janas M, Varano G, Gudmundsson K, Noda M, Nagasawa T, Turner M . Thymic development beyond beta-selection requires phosphatidylinositol 3-kinase activation by CXCR4. J Exp Med. 2009; 207(1):247-61. PMC: 2812547. DOI: 10.1084/jem.20091430. View

Lisignoli G, Toneguzzi S, Pozzi C, Piacentini A, Grassi F, Ferruzzi A . Chemokine expression by subchondral bone marrow stromal cells isolated from osteoarthritis (OA) and rheumatoid arthritis (RA) patients. Clin Exp Immunol. 1999; 116(2):371-8. PMC: 1905276. DOI: 10.1046/j.1365-2249.1999.00893.x. View

Huntington N, Tabarias H, Fairfax K, Brady J, Hayakawa Y, Degli-Esposti M . NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulation. J Immunol. 2007; 178(8):4764-70. DOI: 10.4049/jimmunol.178.8.4764. View

Bonecchi R, Galliera E, Borroni E, Marco Corsi M, Locati M, Mantovani A . Chemokines and chemokine receptors: an overview. Front Biosci (Landmark Ed). 2009; 14(2):540-51. DOI: 10.2741/3261. View

Lanier L . Up on the tightrope: natural killer cell activation and inhibition. Nat Immunol. 2008; 9(5):495-502. PMC: 2669298. DOI: 10.1038/ni1581. View

Peng H, Jiang X, Chen Y, Sojka D, Wei H, Gao X . Liver-resident NK cells confer adaptive immunity in skin-contact inflammation. J Clin Invest. 2013; 123(4):1444-56. PMC: 3613925. DOI: 10.1172/JCI66381. View

10.

Egawa T, Kawabata K, Kawamoto H, Amada K, Okamoto R, Fujii N . The earliest stages of B cell development require a chemokine stromal cell-derived factor/pre-B cell growth-stimulating factor. Immunity. 2001; 15(2):323-34. DOI: 10.1016/s1074-7613(01)00185-6. View

11.

Cichocki F, Felices M, McCullar V, Presnell S, Al-Attar A, Lutz C . Cutting edge: microRNA-181 promotes human NK cell development by regulating Notch signaling. J Immunol. 2011; 187(12):6171-5. PMC: 3237765. DOI: 10.4049/jimmunol.1100835. View

12.

Jones-Mason M, Zhao X, Kappes D, Lasorella A, Iavarone A, Zhuang Y . E protein transcription factors are required for the development of CD4(+) lineage T cells. Immunity. 2012; 36(3):348-61. PMC: 3431168. DOI: 10.1016/j.immuni.2012.02.010. View

13.

Vosshenrich C, Garcia-Ojeda M, Samson-Villeger S, Pasqualetto V, Enault L, Goff O . A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127. Nat Immunol. 2006; 7(11):1217-24. DOI: 10.1038/ni1395. View

14.

Bezman N, Chakraborty T, Bender T, Lanier L . miR-150 regulates the development of NK and iNKT cells. J Exp Med. 2011; 208(13):2717-31. PMC: 3244033. DOI: 10.1084/jem.20111386. View

15.

Ponzetta A, Sciume G, Benigni G, Antonangeli F, Morrone S, Santoni A . CX3CR1 regulates the maintenance of KLRG1+ NK cells into the bone marrow by promoting their entry into circulation. J Immunol. 2013; 191(11):5684-94. DOI: 10.4049/jimmunol.1300090. View

16.

Tokoyoda K, Egawa T, Sugiyama T, Choi B, Nagasawa T . Cellular niches controlling B lymphocyte behavior within bone marrow during development. Immunity. 2004; 20(6):707-18. DOI: 10.1016/j.immuni.2004.05.001. View

17.

Kee B . E and ID proteins branch out. Nat Rev Immunol. 2009; 9(3):175-84. DOI: 10.1038/nri2507. View

18.

Wald O, Weiss I, Wald H, Shoham H, Bar-Shavit Y, Beider K . IFN-gamma acts on T cells to induce NK cell mobilization and accumulation in target organs. J Immunol. 2006; 176(8):4716-29. DOI: 10.4049/jimmunol.176.8.4716. View

19.

Dorfman J, Raulet D . Acquisition of Ly49 receptor expression by developing natural killer cells. J Exp Med. 1998; 187(4):609-18. PMC: 2212149. DOI: 10.1084/jem.187.4.609. View

20.

Henao-Mejia J, Williams A, Goff L, Staron M, Licona-Limon P, Kaech S . The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis. Immunity. 2013; 38(5):984-97. PMC: 3738211. DOI: 10.1016/j.immuni.2013.02.021. View