A Retrospective Analysis of Acute Poisoning During Pregnancy

Overview

Journal J Turk Ger Gynecol Assoc

Publisher Galenos Publishing House

Specialty Gynecology & Obstetrics

Date 2014 Mar 5

PMID 24591994

Authors

Sevdegul Karadas

Ayse Guler

Irfan Aydin

Affiliations

Soon will be listed here.

Abstract

Objective: The aim of this study is to investigate and analyse pregnant women who were admitted to our emergency service due to acute poisoning.

Material And Methods: All cases were retrospectively collected from our computer records and emergency record book between 01.01.2006 and 01.01.2010; the registration data on age, gravidity, gestational week, whether the poisoning was deliberate or accidental, causative agent, admission time, treatment results and mortality outcome were collected and analyzed.

Results: Eighty eight women admitted with acute poisoning were known to be pregnant and the poisoning was accidental in 23% of the cases, while 77% were suicidal intoxications. 74% of patients were in the 21-34 age group. Accidental intoxications were due to carbon monoxide, foods and cleaning products. 75.4% of the suicidal poisonings were caused by medical drugs, with analgesics, multiple drugs and psychiatric drugs being the top culprits and accounted for 53%, 31% and 16% of drug poisonings respectively. In terms of gestational week, 47.4% of suicidal poisonings were within the first trimester and the relationship between suicidal attempt and gestational week was found to be statistically significant (p<0.015). However, the relationship between gravidity and the rate of suicidal attempts was not statistically significant (p=0.214). All patients were followed up and treated in the emergency service and no mortality was observed in the study.

Conclusion: Most cases of acute poisonings during pregnancy were suicidal. Pregnant women attempted suicide mostly within the first trimester of gestation. The most common agents used for suicidal attempt were medical drugs.

References

McClure C, Katz K, Patrick T, Kelsey S, Weiss H . The epidemiology of acute poisonings in women of reproductive age and during pregnancy, California, 2000-2004. Matern Child Health J. 2010; 15(7):964-73. DOI: 10.1007/s10995-010-0571-1. View

Czeizel A, Timar L, Susanszky E . Timing of suicide attempts by self-poisoning during pregnancy and pregnancy outcomes. Int J Gynaecol Obstet. 1999; 65(1):39-45. DOI: 10.1016/s0020-7292(99)00007-7. View

Ahmadi A, Pakravan N, Ghazizadeh Z . Pattern of acute food, drug, and chemical poisoning in Sari City, Northern Iran. Hum Exp Toxicol. 2010; 29(9):731-8. DOI: 10.1177/0960327110361501. View

Watson W, Litovitz T, Rodgers Jr G, Klein-Schwartz W, Youniss J, Rose S . 2002 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med. 2003; 21(5):353-421. DOI: 10.1016/s0735-6757(03)00088-3. View

Perrone J, Hoffman R . Toxic ingestions in pregnancy: abortifacient use in a case series of pregnant overdose patients. Acad Emerg Med. 1997; 4(3):206-9. DOI: 10.1111/j.1553-2712.1997.tb03742.x. View

Karakaya A, Vural N . Acute poisoning admissions in one of the hospitals in Ankara. Hum Toxicol. 1985; 4(3):323-6. DOI: 10.1177/096032718500400314. View

Watson W, Litovitz T, Rodgers Jr G, Klein-Schwartz W, Reid N, Youniss J . 2004 Annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med. 2005; 23(5):589-666. DOI: 10.1016/j.ajem.2005.05.001. View

Lapatto-Reiniluoto O, Kivisto K, LUOMANMAKI K, Neuvonen P . A prospective study of acute poisonings in Finnish hospital patients. Hum Exp Toxicol. 1998; 17(6):307-11. DOI: 10.1177/096032719801700604. View

McMahon G, McGarry K . Deliberate self-poisoning in an Irish county hospital. Ir J Med Sci. 2001; 170(2):94-7; discussion 90. DOI: 10.1007/BF03168817. View

10.

Gandhi S, Gilbert W, McElvy S, El Kady D, Danielson B, Xing G . Maternal and neonatal outcomes after attempted suicide. Obstet Gynecol. 2006; 107(5):984-90. DOI: 10.1097/01.AOG.0000216000.50202.f6. View

11.

Ozkose Z, Ayoglu F . Etiological and demographical characteristics of acute adult poisoning in Ankara, Turkey. Hum Exp Toxicol. 1999; 18(10):614-8. DOI: 10.1191/096032799678839446. View

12.

Hanssens Y, Deleu D, Taqi A . Etiologic and demographic characteristics of poisoning: a prospective hospital-based study in Oman. J Toxicol Clin Toxicol. 2001; 39(4):371-80. DOI: 10.1081/clt-100105158. View

13.

Mert E, Bilgin N . Demographical, aetiological and clinical characteristics of poisonings in Mersin, Turkey. Hum Exp Toxicol. 2006; 25(4):217-23. DOI: 10.1191/0960327106ht612oa. View

14.

Guloglu C, Kara I . Acute poisoning cases admitted to a university hospital emergency department in Diyarbakir, Turkey. Hum Exp Toxicol. 2005; 24(2):49-54. DOI: 10.1191/0960327105ht499oa. View

15.

Bajo Bajo A, Santos Perez M, Sanz Ortega F, Zapico Alvarez N, Okatsu K, Garcia Perez A . [An epidemiological study of acute intoxications and provision of medical-cabinet antidotes]. An Med Interna. 1999; 16(6):285-9. View

16.

Rayburn W, ARONOW R, DeLancey B, Hogan M . Drug overdose during pregnancy: an overview from a metropolitan poison control center. Obstet Gynecol. 1984; 64(5):611-4. View

17.

Goksu S, Yildirim C, Kocoglu H, Tutak A, Oner U . Characteristics of acute adult poisoning in Gaziantep, Turkey. J Toxicol Clin Toxicol. 2003; 40(7):833-7. DOI: 10.1081/clt-120016953. View

18.

Pinar A, Fowler J, Bond G . Acute poisoning in Izmir, Turkey--a pilot epidemiologic study. J Toxicol Clin Toxicol. 1993; 31(4):593-601. DOI: 10.3109/15563659309025764. View

19.

Islambulchilar M, Islambulchilar Z, Kargar-Maher M . Acute adult poisoning cases admitted to a university hospital in Tabriz, Iran. Hum Exp Toxicol. 2009; 28(4):185-90. DOI: 10.1177/0960327108099679. View