HLA-G Polymorphism (rs16375) and Acute Rejection in Liver Transplant Recipients

Overview

Journal Dis Markers

Publisher Wiley

Specialty Biochemistry

Date 2014 Mar 5

PMID 24591768

Citations 3

Authors

Negar Azarpira

Mahdokht H Aghdaie

Kurosh Kazemi

Bita Geramizadeh

Masumeh Darai

Affiliations

Soon will be listed here.

Abstract

Background: HLA-G molecules exhibit immunomodulatory properties that can delay graft rejection. The 14 bp insertion/deletion polymorphism (INDEL) (rs16375) influences the stability of final HLA-G mRNA and its soluble isoforms.

Objective: The present study aimed to investigate the possible association between this polymorphism and the incidence of acute rejection in Iranian liver transplant recipients.

Methods: Different genotypes were evaluated by PCR. The patients who had acute rejection within 6 months after transplantation were classified as acute rejection (AR) group, while others were considered as nonacute rejection (NAR) group.

Results: Among the recipients, 21 patients (21%) had at least one episode of AR, while the other 79 patients (79%) had normal liver function. No significant differences were found between the two groups regarding sex, MELD score, and primary liver disease. Also, no difference was observed concerning rs16375 genotype and allele frequency (P = 0.44, OR: 0.69; CI: 0.21-2.10).

Conclusion: The study results revealed no significant difference between the AR and the NAR groups regarding the 14 bp INDEL genotypes and alleles. Further studies are recommended to be conducted on other polymorphic sites as well as monitoring of serum HLA-G concentration in order to ascertain the potential implications of this marker in our population.

Citing Articles

Biological Characteristics of HLA-G and Its Role in Solid Organ Transplantation.

Liu S, Bos N, Verschuuren E, van Baarle D, Westra J Front Immunol. 2022; 13:902093.

PMID: 35769475 PMC: 9234285. DOI: 10.3389/fimmu.2022.902093.

Interleukin-28B rs12979860 C/T Polymorphism and Acute Cellular Rejection after Liver Transplantation.

Fereidooni H, Azarpira N, Yaghobi R, Vahdati A, Malek-Hoseini S Int J Organ Transplant Med. 2017; 8(1):28-33.

PMID: 28299025 PMC: 5347403.

Tolerogenic Dendritic Cells on Transplantation: Immunotherapy Based on Second Signal Blockage.

Silva P, Bier J, Paiatto L, Galdino Albuquerque C, Souza C, Fernandes L J Immunol Res. 2015; 2015:856707.

PMID: 26543876 PMC: 4620289. DOI: 10.1155/2015/856707.

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