KE and EE Genotypes of ICAM-1 Gene K469E Polymorphism is Associated with Severe Preeclampsia

Overview

Journal Dis Markers

Publisher Wiley

Specialty Biochemistry

Date 2014 Mar 5

PMID 24591755

Citations 4

Authors

Ehsan Tabatabai

Saeedeh Salimi

Milad Mohammadoo-Khorasani

Minoo Yaghmaei

Mojgan Mokhtari

Farzaneh Farajian Mashhadi

Anoosh Naghavi

Affiliations

Soon will be listed here.

Abstract

Background: Preeclampsia (PE) is one of the most important complications of pregnancy that is associated with significant mortality and morbidity in mother and fetus. Since the etiologic factors in its development are still unclear, we aimed to examine the intercellular adhesion molecule-1 (ICAM-1) gene K469E polymorphism in preeclamptic and control healthy women.

Materials And Methods: Genetic polymorphism was analyzed in 192 PE and 186 healthy control women. PCR-RFLP method was used to identify K469E polymorphism.

Results: The frequency of KK, KE, and EE genotypes of ICAM-1 gene was not different between PE patients and healthy pregnant women. Whereas, the frequency of KE and EE genotypes was significantly higher in severe PE than mild PE women and control group, and the risk of severe PE was 2.4-fold higher in subjects with KE genotype (OR, 2.4 [95% CI, 1 to 5.9]; P = 0.03) and 3.3-fold higher in subjects with EE genotype (OR, 3.3 [95% CI, 1.2 to 9]; P = 0.015) compared to individuals with KK genotype.

Conclusion: We concluded that KE and EE genotypes of K469E polymorphism could increase risk of severe PE.

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