Polymorphisms of ATF6B Are Potentially Associated With FEV1 Decline by Aspirin Provocation in Asthmatics

Overview

Journal Allergy Asthma Immunol Res

Date 2014 Mar 4

PMID 24587951

Citations 3

Authors

Tae-Joon Park

Jeong-Hyun Kim

Charisse F Pasaje

Byung-Lae Park

Joon Seol Bae

Soo-Taek Uh

Yong-Hoon Kim

Mi-Kyeong Kim

Inseon S Choi

Byoung Whui Choi

Hye-Rim Shin

Jong-Sook Park

Insong Koh

Choon-Sik Park

Hyoung Doo Shin

Affiliations

Soon will be listed here.

Abstract

Purpose: Endoplasmic reticulum (ER) stress has recently been observed to activate NF-kappaB and induce inflammatory responses such as asthma. Activating transcription factor 6β (ATF6B) is known to regulate ATFα-mediated ER stress response. The aim of this study is to investigate the associations of ATF6B genetic variants with aspirin-exacerbated respiratory disease (AERD) and its major phenotype, % decline of FEV1 by aspirin provocation.

Methods: Four common single nucleotide polymorphisms (SNPs) of ATF6B were genotyped and statistically analyzed in 93 AERD patients and 96 aspirin-tolerant asthma (ATA) as controls.

Results: Logistic analysis revealed that 2 SNPs (rs2228628 and rs8111, P=0.008; corrected P=0.03) and 1 haplotype (ATF6B-ht4, P=0.005; corrected P=0.02) were significantly associated with % decline of FEV1 by aspirin provocation, whereas ATF6B polymorphisms and haplotypes were not associated with the risk of AERD.

Conclusions: Although further functional and replication studies are needed, our preliminary findings suggest that ATF6B may be related to obstructive phenotypes in response to aspirin exposure in adult asthmatics.

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