Usefulness of Intraoperative Continuous Infusion of Tranexamic Acid During Emergency Surgery for Type A Acute Aortic Dissection

Overview

Journal Ann Thorac Cardiovasc Surg

Specialties Cardiology & Vascular Diseases
General Surgery
Pulmonary Medicine

Date 2014 Mar 4

PMID 24583703

Citations 4

Authors

Kun Tae Ahn

Kazuo Yamanaka

Atsushi Iwakura

Keiichi Hirose

Daisuke Nakatsuka

Takayoshi Kusuhara

Jin Ikarashi

Affiliations

Soon will be listed here.

Abstract

Purpose: We investigated the influence of intraoperative continuous tranexamic acid (TA) infusion on the amount of blood transfusion required in emergency surgery for type A acute aortic dissection.

Methods: The study was based on the data of 55 consecutive patients who underwent surgery for type A acute aortic dissection. The patients were divided into 2 groups for comparison: Group T, consisting of 26 patients who received intraoperative continuous infusion of TA, and Group N, consisting of 29 patients who did not receive TA infusion during the surgery.

Results: The mean amounts of blood transfusion required during and after surgery were compared between the 2 groups: they were 10.5 ± 8.7 and 16.2 ± 10.0 units of mannitol-adenine-phosphate-added red cell concentrate, 9.3 ± 8.6 and 17.1 ± 10.0 units of fresh frozen plasma, and 20.4 ± 12.2 and 29.7 ± 14.9 units of platelet concentrate, respectively, in Groups T and N. Thus, the amount of each of these blood products required was significantly reduced in Group T.

Conclusions: During emergency surgery for type A acute aortic dissection, continuous infusion of TA resulted in a significant reduction in the amount of blood transfusion required.

Citing Articles

Intravenous Tranexamic Acid Reduces Post-Operative Bleeding and Blood Transfusion in Patients Undergoing Aortic Surgery: A PRISMA-Compliant Systematic Review and Meta-Analysis.

Zhang B, He L, Yao Y Rev Cardiovasc Med. 2024; 24(4):120.

PMID: 39076261 PMC: 11273041. DOI: 10.31083/j.rcm2404120.

Tranexamic acid - a promising hemostatic agent with limitations: a narrative review.

Kim D, Cho S, Jung K Korean J Anesthesiol. 2023; 77(4):411-422.

PMID: 37599607 PMC: 11294883. DOI: 10.4097/kja.23530.

High-Dose Tranexamic Acid in Patients Underwent Surgical Repair of Aortic Dissection Might Reduce Postoperative Blood Loss: A Cohort Analysis.

Guo J, Cao L, Wang H, Liu G, Zhou Y, Yang L Front Surg. 2022; 9:898579.

PMID: 35774387 PMC: 9237523. DOI: 10.3389/fsurg.2022.898579.

Effect of massive blood transfusion on late outcomes after surgical repair of acute type A aortic dissection.

Chen F, Chou A, Wu V, Yang C, Chu P, Ting P Medicine (Baltimore). 2019; 98(45):e17816.

PMID: 31702635 PMC: 6855666. DOI: 10.1097/MD.0000000000017816.

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