Non-homologous End Joining: Emerging Themes and Unanswered Questions

Overview

Journal DNA Repair (Amst)

Publisher Elsevier

Specialties Biochemistry
Molecular Biology

Date 2014 Mar 4

PMID 24582502

Citations 72

Authors

Sarvan Kumar Radhakrishnan

Nicholas Jette

Susan P Lees-Miller

Affiliations

Soon will be listed here.

Abstract

Non-homologous end joining (NHEJ) is the major pathway for the repair of ionizing radiation induced DNA double strand breaks in human cells. Here, we discuss current insights into the mechanism of NHEJ and the interplay between NHEJ and other pathways for repair of IR-induced DNA damage.

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