Activated Microglia Do Not Form Functional Gap Junctions in Vivo

Overview

Journal J Neuroimmunol

Specialty Neurology

Date 2014 Mar 4

PMID 24582000

Citations 16

Authors

Sameh K Wasseff

Steven S Scherer

Affiliations

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Abstract

We investigated whether microglia form gap junctions with themselves, or with astrocytes, oligodendrocytes, or neurons in vivo in normal mouse brains, and in pathological conditions that induce microglial activation - brain injury and a model of Alzheimer's disease. Although microglia are in close physical proximity to glia and neurons, they do not form functional gap junctions under these pathological conditions.

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