8-year Survival in a Patient with Several Recurrences of Renal Cell Carcinoma After Radical Nephrectomy

Overview

Journal Cent European J Urol

Specialty Urology

Date 2014 Mar 1

PMID 24578974

Citations 4

Authors

Shivam Joshi

Ahmed Eldefrawy

Gaetano Ciancio

Affiliations

Soon will be listed here.

Abstract

We describe the case of a patient with a large renal cell carcinoma (RCC) who underwent cytoreductive nephrectomy utilizing liver mobilization techniques similar to those used in transplantation. Despite recurrent metastases, our patient continues to survive eight years later with several metastasectomies and adjuvant chemotherapy. We report the case of a 48-year-old Hispanic American man who presented with a 4-month history of an enlarging right upper quadrant abdominal mass and hematuria. Computerized tomography revealed a 13 x 14 x 14 centimeter mass suspicious of RCC with possible metastasis to the lungs. The patient subsequently underwent radical nephrectomy. Pathological analysis confirmed the mass as RCC. Over the following eight years, the patient developed metastases to the pulmonary lobes, buccal mucosa, thoracic spine, and second rib, which were all treated with metastasectomy. The patient continues to survive today with a reasonable quality of life. Palliative measures in patients with large RCC tumors with distant metastases require persistent, aggressive therapeutic modalities.

Citing Articles

Foley catheter-assisted six-step thrombectomy technique in the surgical management of renal cell carcinoma with Mayo level II to IV tumor thrombus.

Liu Z, Tang S, Tian X, Zhang S, Wang G, Zhang H J Int Med Res. 2019; 47(5):2104-2115.

PMID: 30922138 PMC: 6567778. DOI: 10.1177/0300060519836912.

Modified technique of cavoatrial tumor thrombectomy without cardiopulmonary by-pass and hypothermic circulatory arrest: a preliminary report.

Sobczynski R, Golabek T, Przydacz M, Wiatr T, Bukowczan J, Sadowski J Cent European J Urol. 2015; 68(3):311-7.

PMID: 26568872 PMC: 4643704. DOI: 10.5173/ceju.2015.588.

Is there a role for systemic targeted therapy after surgical treatment for metastases of renal cell carcinoma?.

Husillos Alonso A, Carbonero Garcia M, Gonzalez Enguita C World J Nephrol. 2015; 4(2):254-62.

PMID: 25949939 PMC: 4419135. DOI: 10.5527/wjn.v4.i2.254.

The incidence of renal cancer in Polish National Cancer Registry: is there any epidemiological data we can rely on?.

Wojcieszak P, Poletajew S, Rutkowski D, Radziszewski P Cent European J Urol. 2014; 67(3):253-6.

PMID: 25247082 PMC: 4165683. DOI: 10.5173/ceju.2014.03.art8.

References

Ciancio G, Gonzalez J, Shirodkar S, Angulo J, Soloway M . Liver transplantation techniques for the surgical management of renal cell carcinoma with tumor thrombus in the inferior vena cava: step-by-step description. Eur Urol. 2010; 59(3):401-6. DOI: 10.1016/j.eururo.2010.07.028. View

Kavolius J, Mastorakos D, Pavlovich C, Russo P, Burt M, Brady M . Resection of metastatic renal cell carcinoma. J Clin Oncol. 1998; 16(6):2261-6. DOI: 10.1200/JCO.1998.16.6.2261. View

Alt A, Boorjian S, Lohse C, Costello B, Leibovich B, Blute M . Survival after complete surgical resection of multiple metastases from renal cell carcinoma. Cancer. 2011; 117(13):2873-82. DOI: 10.1002/cncr.25836. View

Shiraishi K, Mohri J, Inoue R, Kamiryo Y . Metastatic renal cell carcinoma to the bladder 12 years after radical nephrectomy. Int J Urol. 2003; 10(8):453-5. DOI: 10.1046/j.1442-2042.2003.00652.x. View

Flanigan R . Debulking nephrectomy in metastatic renal cancer. Clin Cancer Res. 2004; 10(18 Pt 2):6335S-41S. DOI: 10.1158/1078-0432.CCR-sup-040026. View

Eggener S, Yossepowitch O, Kundu S, Motzer R, Russo P . Risk score and metastasectomy independently impact prognosis of patients with recurrent renal cell carcinoma. J Urol. 2008; 180(3):873-8. PMC: 2570431. DOI: 10.1016/j.juro.2008.05.006. View

Ciancio G, Livingstone A, Soloway M . Surgical management of renal cell carcinoma with tumor thrombus in the renal and inferior vena cava: the University of Miami experience in using liver transplantation techniques. Eur Urol. 2006; 51(4):988-94. DOI: 10.1016/j.eururo.2006.11.055. View

Leibovich B, Cheville J, Lohse C, Zincke H, Frank I, Kwon E . A scoring algorithm to predict survival for patients with metastatic clear cell renal cell carcinoma: a stratification tool for prospective clinical trials. J Urol. 2005; 174(5):1759-63. DOI: 10.1097/01.ju.0000177487.64651.3a. View

Vaidya A, Ciancio G, Soloway M . Surgical techniques for treating a renal neoplasm invading the inferior vena cava. J Urol. 2003; 169(2):435-44. DOI: 10.1097/01.ju.0000047230.49976.bf. View

10.

Szendroi A, Szendroi M, Szucs M, Szekely E, Romics I . 11-year survival of a renal cell cancer patient following multiple metastasectomy. Can J Urol. 2010; 17(6):5475-7. View

11.

Buti S, Rovere R . Renal cell cancer: state of the art in adjuvant therapy. Recent Pat Anticancer Drug Discov. 2010; 5(3):242-50. DOI: 10.2174/157489210791760544. View

12.

Ciancio G, Hawke C, Soloway M . The use of liver transplant techniques to aid in the surgical management of urological tumors. J Urol. 2000; 164(3 Pt 1):665-72. DOI: 10.1097/00005392-200009010-00012. View

13.

Vogl U, Zehetgruber H, Dominkus M, Hejna M, Zielinski C, Haitel A . Prognostic factors in metastatic renal cell carcinoma: metastasectomy as independent prognostic variable. Br J Cancer. 2006; 95(6):691-8. PMC: 2360513. DOI: 10.1038/sj.bjc.6603327. View

14.

Kierney P, Van Heerden J, Segura J, Weaver A . Surgeon's role in the management of solitary renal cell carcinoma metastases occurring subsequent to initial curative nephrectomy: an institutional review. Ann Surg Oncol. 1994; 1(4):345-52. DOI: 10.1007/BF02303572. View

15.

Jemal A, Siegel R, Xu J, Ward E . Cancer statistics, 2010. CA Cancer J Clin. 2010; 60(5):277-300. DOI: 10.3322/caac.20073. View

16.

Jocham D, Richter A, Hoffmann L, Iwig K, Fahlenkamp D, Zakrzewski G . Adjuvant autologous renal tumour cell vaccine and risk of tumour progression in patients with renal-cell carcinoma after radical nephrectomy: phase III, randomised controlled trial. Lancet. 2004; 363(9409):594-9. DOI: 10.1016/S0140-6736(04)15590-6. View

17.

Pantuck A, Zisman A, Belldegrun A . The changing natural history of renal cell carcinoma. J Urol. 2001; 166(5):1611-23. View