Genetic Dysbiosis: the Role of Microbial Insults in Chronic Inflammatory Diseases

Overview

Journal J Oral Microbiol

Specialty Dentistry

Date 2014 Mar 1

PMID 24578801

Citations 33

Authors

Luigi Nibali

Brian Henderson

Syed Tariq Sadiq

Nikos Donos

Affiliations

Soon will be listed here.

Abstract

Thousands of bacterial phylotypes colonise the human body and the host response to this bacterial challenge greatly influences our state of health or disease. The concept of infectogenomics highlights the importance of host genetic factors in determining the composition of human microbial biofilms and the response to this microbial challenge. We hereby introduce the term 'genetic dysbiosis' to highlight the role of human genetic variants affecting microbial recognition and host response in creating an environment conducive to changes in the normal microbiota. Such changes can, in turn, predispose to, and influence, diseases such as: cancer, inflammatory bowel disease, rheumatoid arthritis, psoriasis, bacterial vaginosis and periodontitis. This review presents the state of the evidence on host genetic factors affecting dysbiosis and microbial misrecognition (i.e. an aberrant response to the normal microbiota) and highlights the need for further research in this area.

Citing Articles

Grade C Molar-Incisor Pattern Periodontitis in Young Adults: What Have We Learned So Far?.

Miguel M, Shaddox L Pathogens. 2024; 13(7).

PMID: 39057807 PMC: 11279578. DOI: 10.3390/pathogens13070580.

Associations between Host Genetic Variants and Subgingival Microbiota in Patients with the Metabolic Syndrome.

Nibali L, Stephen A, Allaker R, Di Pino A, Terranova V, Pisano M Int J Mol Sci. 2023; 24(23).

PMID: 38068972 PMC: 10706808. DOI: 10.3390/ijms242316649.

Biofilm's Impact on Inflammatory Bowel Diseases.

Palandurkar G, Kumar S Cureus. 2023; 15(9):e45510.

PMID: 37868553 PMC: 10585119. DOI: 10.7759/cureus.45510.

Subgingival Microbiota and Periodontal Clinical Status in Patients with Plaque Psoriasis: A Cross-Sectional Study.

Orozco-Molina G, Casillas-Santana M, Flores-Ledesma A, Martinez-Arroniz F, Castaneda-Saucedo E, Martinez-Aguilar V Indian J Dermatol. 2023; 68(2):161-169.

PMID: 37275812 PMC: 10238986. DOI: 10.4103/ijd.ijd_394_22.

Metabolic-Dysfunction-Associated Fatty Liver Disease and Gut Microbiota: From Fatty Liver to Dysmetabolic Syndrome.

Abenavoli L, Scarlata G, Scarpellini E, Boccuto L, Spagnuolo R, Tilocca B Medicina (Kaunas). 2023; 59(3).

PMID: 36984595 PMC: 10054528. DOI: 10.3390/medicina59030594.

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