Novel Activating STAT5B Mutations As Putative Drivers of T-cell Acute Lymphoblastic Leukemia

Overview

Journal Leukemia

Specialties Hematology
Oncology

Date 2014 Feb 28

PMID 24573384

Citations 62

Authors

M Kontro

H Kuusanmaki

S Eldfors

T Burmeister

E I Andersson

O Bruserud

T H Brummendorf

H Edgren

B T Gjertsen

M Itala-Remes

S Lagstrom

O Lohi

T Lundan

J M L Marti

M M Majumder

A Parsons

T Pemovska

H Rajala

K Vettenranta

O Kallioniemi

S Mustjoki

K Porkka

C A Heckman

Affiliations

Soon will be listed here.

Citing Articles

STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs.

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Infections in Inborn Errors of STATs.

Wang C, Freeman A Pathogens. 2024; 13(11).

PMID: 39599507 PMC: 11597637. DOI: 10.3390/pathogens13110955.

PIM1 is a potential therapeutic target for the leukemogenic effects mediated by JAK/STAT pathway mutations in T-ALL/LBL.

Lahera A, Vela-Martin L, Fernandez-Navarro P, Llamas P, Lopez-Lorenzo J, Cornago J NPJ Precis Oncol. 2024; 8(1):152.

PMID: 39033228 PMC: 11271448. DOI: 10.1038/s41698-024-00638-2.

Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.

Suske T, Sorger H, Manhart G, Ruge F, Prutsch N, Zimmerman M J Clin Invest. 2024; 134(8).

PMID: 38618957 PMC: 11014662. DOI: 10.1172/JCI168536.

A lineage-specific STAT5BN642H mouse model to study NK-cell leukemia.

Klein K, Kollmann S, Hiesinger A, List J, Kendler J, Klampfl T Blood. 2024; 143(24):2474-2489.

PMID: 38498036 PMC: 11208297. DOI: 10.1182/blood.2023022655.

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