Proteomics and Diabetic Nephropathy: What Have We Learned from a Decade of Clinical Proteomics Studies?

Overview

Journal J Nephrol

Publisher Springer

Specialty Nephrology

Date 2014 Feb 26

PMID 24567069

Citations 8

Authors

Massimo Papale

Salvatore Di Paolo

Grazia Vocino

Maria Teresa Rocchetti

Loreto Gesualdo

Affiliations

Soon will be listed here.

Abstract

Diabetic nephropathy (DN) has become the most frequent cause of chronic kidney disease worldwide due to the constant increase of the incidence of type 2 diabetes mellitus in developed and developing countries. The understanding of the pathophysiological mechanisms of human diseases through a large-scale characterization of the protein content of a biological sample is the key feature of the proteomics approach to the study of human disease. We discuss the main results of over 10 years of tissue and urine proteomics studies applied to DN in order to understand how far we have come and how far we still have to go before obtaining a full comprehension of the molecular mechanisms involved in the pathogenesis of DN and identifying reliable biomarkers for accurate management of patients.

Citing Articles

Stratification of diabetic kidney diseases data-independent acquisition proteomics-based analysis of human kidney tissue specimens.

Huang Q, Fei X, Zhong Z, Zhou J, Gong J, Chen Y Front Endocrinol (Lausanne). 2022; 13:995362.

PMID: 36465646 PMC: 9714485. DOI: 10.3389/fendo.2022.995362.

Proteomic Study of Low-Birth-Weight Nephropathy in Rats.

Imasawa T, Claverol S, Lacombe D, Dias Amoedo N, Rossignol R Int J Mol Sci. 2021; 22(19).

PMID: 34638634 PMC: 8508940. DOI: 10.3390/ijms221910294.

Strategies to improve monitoring disease progression, assessing cardiovascular risk, and defining prognostic biomarkers in chronic kidney disease.

Pena M, Stenvinkel P, Kretzler M, Adu D, Agarwal S, Coresh J Kidney Int Suppl (2011). 2019; 7(2):107-113.

PMID: 30675424 PMC: 6341006. DOI: 10.1016/j.kisu.2017.07.005.

A more tubulocentric view of diabetic kidney disease.

Zeni L, Norden A, Cancarini G, Unwin R J Nephrol. 2017; 30(6):701-717.

PMID: 28840540 PMC: 5698396. DOI: 10.1007/s40620-017-0423-9.

Proteomics for prediction of disease progression and response to therapy in diabetic kidney disease.

Pena M, Mischak H, Heerspink H Diabetologia. 2016; 59(9):1819-31.

PMID: 27344310 PMC: 4969331. DOI: 10.1007/s00125-016-4001-9.

References

Ziyadeh F, Snipes E, Watanabe M, Alvarez R, Goldfarb S, Haverty T . High glucose induces cell hypertrophy and stimulates collagen gene transcription in proximal tubule. Am J Physiol. 1990; 259(4 Pt 2):F704-14. DOI: 10.1152/ajprenal.1990.259.4.F704. View

Chua Jr S, Chung W, Wu-Peng X, Zhang Y, Liu S, Tartaglia L . Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science. 1996; 271(5251):994-6. DOI: 10.1126/science.271.5251.994. View

Thongboonkerd V . Current status of renal and urinary proteomics: ready for routine clinical application?. Nephrol Dial Transplant. 2009; 25(1):11-6. DOI: 10.1093/ndt/gfp476. View

Santucci L, Candiano G, Bruschi M, Bodria M, Murtas C, Petretto A . Urinary proteome in a snapshot: normal urine and glomerulonephritis. J Nephrol. 2012; 26(4):610-6. DOI: 10.5301/jn.5000233. View

Barratt J, Topham P . Urine proteomics: the present and future of measuring urinary protein components in disease. CMAJ. 2007; 177(4):361-8. PMC: 1942114. DOI: 10.1503/cmaj.061590. View

Magni F, Lalowski M, Mainini V, Marchetti-Deschmann M, Chinello C, Urbani A . Proteomics imaging and the kidney. J Nephrol. 2013; 26(3):430-6. DOI: 10.5301/jn.5000243. View

Papale M, Di Paolo S, Magistroni R, Lamacchia O, Di Palma A, De Mattia A . Urine proteome analysis may allow noninvasive differential diagnosis of diabetic nephropathy. Diabetes Care. 2010; 33(11):2409-15. PMC: 2963504. DOI: 10.2337/dc10-0345. View

Krolewski A, Warram J . Genetic susceptibility to diabetic kidney disease: an update. J Diabetes Complications. 1995; 9(4):277-81. DOI: 10.1016/1056-8727(95)80021-6. View

Kolch W, Neususs C, Pelzing M, Mischak H . Capillary electrophoresis-mass spectrometry as a powerful tool in clinical diagnosis and biomarker discovery. Mass Spectrom Rev. 2005; 24(6):959-77. DOI: 10.1002/mas.20051. View

10.

Kim H, Cho E, Yoo J, Kim P, Shin J, Kim M . Proteome analysis of serum from type 2 diabetics with nephropathy. J Proteome Res. 2007; 6(2):735-43. DOI: 10.1021/pr060489g. View

11.

Matsuda K, Chung J, Hewitt S . Histo-proteomic profiling of formalin-fixed, paraffin-embedded tissue. Expert Rev Proteomics. 2010; 7(2):227-37. PMC: 7556735. DOI: 10.1586/epr.09.106. View

12.

Kurtz T, Morris R, Pershadsingh H . The Zucker fatty rat as a genetic model of obesity and hypertension. Hypertension. 1989; 13(6 Pt 2):896-901. DOI: 10.1161/01.hyp.13.6.896. View

13.

Rossing K, Mischak H, Dakna M, Zurbig P, Novak J, Julian B . Urinary proteomics in diabetes and CKD. J Am Soc Nephrol. 2008; 19(7):1283-90. PMC: 2440301. DOI: 10.1681/ASN.2007091025. View

14.

Zurbig P, Jerums G, Hovind P, MacIsaac R, Mischak H, Nielsen S . Urinary proteomics for early diagnosis in diabetic nephropathy. Diabetes. 2012; 61(12):3304-13. PMC: 3501878. DOI: 10.2337/db12-0348. View

15.

Craig K, Donovan K, Munnery M, Owens D, Williams J, Phillips A . Identification and management of diabetic nephropathy in the diabetes clinic. Diabetes Care. 2003; 26(6):1806-11. DOI: 10.2337/diacare.26.6.1806. View

16.

Barati M, Merchant M, Kain A, Jevans A, McLeish K, Klein J . Proteomic analysis defines altered cellular redox pathways and advanced glycation end-product metabolism in glomeruli of db/db diabetic mice. Am J Physiol Renal Physiol. 2007; 293(4):F1157-65. DOI: 10.1152/ajprenal.00411.2006. View

17.

Papale M, Pedicillo M, Thatcher B, Di Paolo S, Lo Muzio L, Bufo P . Urine profiling by SELDI-TOF/MS: monitoring of the critical steps in sample collection, handling and analysis. J Chromatogr B Analyt Technol Biomed Life Sci. 2007; 856(1-2):205-13. DOI: 10.1016/j.jchromb.2007.06.001. View

18.

Ziyadeh F, Sharma K . Overview: combating diabetic nephropathy. J Am Soc Nephrol. 2003; 14(5):1355-7. DOI: 10.1097/01.asn.0000065608.37756.58. View

19.

Theodorescu D, Wittke S, Ross M, Walden M, Conaway M, Just I . Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis. Lancet Oncol. 2006; 7(3):230-40. DOI: 10.1016/S1470-2045(06)70584-8. View

20.

Yamamoto T, Langham R, Ronco P, Knepper M, Thongboonkerd V . Towards standard protocols and guidelines for urine proteomics: a report on the Human Kidney and Urine Proteome Project (HKUPP) symposium and workshop, 6 October 2007, Seoul, Korea and 1 November 2007, San Francisco, CA, USA. Proteomics. 2008; 8(11):2156-9. DOI: 10.1002/pmic.200800138. View