A Steroid-mimicking Nanomaterial That Mediates Inhibition of Human Lung Mast Cell Responses

Overview

Journal Nanomedicine

Publisher Elsevier

Specialties Biomedical Engineering
Biotechnology

Date 2014 Feb 26

PMID 24566277

Citations 3

Authors

Anthony L Dellinger

Zhiguo Zhou

Christopher L Kepley

Affiliations

Soon will be listed here.

Abstract

From The Clinical Editor: This study investigates the role and mechanism of action of fullerenes in deactivating mast cell-based inflammation, paving the way to the development of a novel, non-steroid therapy in reactive airway disease.

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References

Zhou Z, Lenk R, Dellinger A, Wilson S, Sadler R, Kepley C . Liposomal formulation of amphiphilic fullerene antioxidants. Bioconjug Chem. 2010; 21(9):1656-61. PMC: 2941224. DOI: 10.1021/bc1001664. View

Schacke H, Docke W, Asadullah K . Mechanisms involved in the side effects of glucocorticoids. Pharmacol Ther. 2002; 96(1):23-43. DOI: 10.1016/s0163-7258(02)00297-8. View

Zhao W, Kepley C, Morel P, Okumoto L, Fukuoka Y, Schwartz L . Fc gamma RIIa, not Fc gamma RIIb, is constitutively and functionally expressed on skin-derived human mast cells. J Immunol. 2006; 177(1):694-701. PMC: 2176083. DOI: 10.4049/jimmunol.177.1.694. View

Norton S, Dellinger A, Zhou Z, Lenk R, MacFarland D, Vonakis B . A new class of human mast cell and peripheral blood basophil stabilizers that differentially control allergic mediator release. Clin Transl Sci. 2010; 3(4):158-69. PMC: 5350695. DOI: 10.1111/j.1752-8062.2010.00212.x. View

Zhang Y, Dong C . MAP kinases in immune responses. Cell Mol Immunol. 2005; 2(1):20-7. View

Black J, Oliver B, Roth M . Molecular mechanisms of combination therapy with inhaled corticosteroids and long-acting beta-agonists. Chest. 2009; 136(4):1095-1100. DOI: 10.1378/chest.09-0354. View

Farooq A, Zhou M . Structure and regulation of MAPK phosphatases. Cell Signal. 2004; 16(7):769-79. DOI: 10.1016/j.cellsig.2003.12.008. View

Norton S, Wijesinghe D, Dellinger A, Sturgill J, Zhou Z, Barbour S . Epoxyeicosatrienoic acids are involved in the C(70) fullerene derivative-induced control of allergic asthma. J Allergy Clin Immunol. 2012; 130(3):761-769.e2. PMC: 3955256. DOI: 10.1016/j.jaci.2012.04.023. View

Adiseshaiah P, Dellinger A, MacFarland D, Stern S, Dobrovolskaia M, Ileva L . A novel gadolinium-based trimetasphere metallofullerene for application as a magnetic resonance imaging contrast agent. Invest Radiol. 2013; 48(11):745-54. DOI: 10.1097/RLI.0b013e318294de5d. View

10.

Kepley C, Cohen N . Evidence for human mast cell nonreleaser phenotype. J Allergy Clin Immunol. 2003; 112(2):457-9. DOI: 10.1067/mai.2003.1671. View

11.

Galli S, Tsai M, Piliponsky A . The development of allergic inflammation. Nature. 2008; 454(7203):445-54. PMC: 3573758. DOI: 10.1038/nature07204. View

12.

Zhou Z, Joslin S, Dellinger A, Ehrich M, Brooks B, Ren Q . A novel class of compounds with cutaneous wound healing properties. J Biomed Nanotechnol. 2011; 6(5):605-11. DOI: 10.1166/jbn.2010.1157. View

13.

Dellinger A, Zhou Z, Norton S, Lenk R, Conrad D, Kepley C . Uptake and distribution of fullerenes in human mast cells. Nanomedicine. 2010; 6(4):575-82. PMC: 2888797. DOI: 10.1016/j.nano.2010.01.008. View

14.

Geetha N, Mihaly J, Stockenhuber A, Blasi F, Uhrin P, Binder B . Signal integration and coincidence detection in the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) cascade: concomitant activation of receptor tyrosine kinases and of LRP-1 leads to sustained ERK phosphorylation via.... J Biol Chem. 2011; 286(29):25663-74. PMC: 3138245. DOI: 10.1074/jbc.M111.221903. View

15.

Huang C, Tan T . DUSPs, to MAP kinases and beyond. Cell Biosci. 2012; 2(1):24. PMC: 3406950. DOI: 10.1186/2045-3701-2-24. View

16.

Kassel O, Sancono A, Kratzschmar J, Kreft B, Stassen M, Cato A . Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1. EMBO J. 2001; 20(24):7108-16. PMC: 125780. DOI: 10.1093/emboj/20.24.7108. View

17.

Jin Y, Hu D, Peterson E, Eng C, Levin A, Wells K . Dual-specificity phosphatase 1 as a pharmacogenetic modifier of inhaled steroid response among asthmatic patients. J Allergy Clin Immunol. 2010; 126(3):618-25.e1-2. PMC: 2943151. DOI: 10.1016/j.jaci.2010.06.007. View

18.

Lin Y, Yang J . Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling. J Biol Chem. 2005; 281(2):915-26. DOI: 10.1074/jbc.M508720200. View

19.

Clark A . Anti-inflammatory functions of glucocorticoid-induced genes. Mol Cell Endocrinol. 2007; 275(1-2):79-97. DOI: 10.1016/j.mce.2007.04.013. View

20.

Claxson A, Morris C, Blake D, SIREN M, Halliwell B, Gustafsson T . The anti-inflammatory effects of D-myo-inositol-1.2.6-trisphosphate (PP56) on animal models of inflammation. Agents Actions. 1990; 29(1-2):68-70. DOI: 10.1007/BF01964724. View