Evaluation of Antioxidant and Antiangiogenic Properties of Caesalpinia Echinata Extracts

Overview

Journal J Cancer

Specialty Oncology

Date 2014 Feb 25

PMID 24563668

Citations 2

Authors

Elisangela Christhianne Barbosa da Silva Gomes

George Chaves Jimenez

Luis Claudio Nascimento da Silva

Fabricio Bezerra de Sa

Karen Pena Cavalcanti de Souza

Gerson S Paiva

Ivone Antonia de Souza

Affiliations

Soon will be listed here.

Abstract

Natural products contain important combinations of ingredients, which may to some extent help to modulate the effects produced by oxidation substrates in biological systems. It is known that substances capable of modulating the action of these oxidants on tissue may be important allies in the control of neovascularization in pathological processes. The aim of this study was to evaluate the antioxidant and antiangiogenic properties of an ethanol extract of Caesalpinia echinata. The evaluation of antioxidant properties was tested using two methods (DPPH inhibition and sequestration of nitric oxide). The antiangiogenic properties were evaluated using the inflammatory angiogenesis model in the corneas of rats. The extract of C. echinata demonstrated a high capacity to inhibit free radicals, with IC50 equal to 42.404 µg/mL for the DPPH test and 234.2 µg/mL for nitric oxide. Moreover, it showed itself capable of inhibiting the inflammatory angiogenic response by 77.49%. These data suggest that biochemical components belonging to the extract of C. echinata interfere in mechanisms that control the angiogenic process, mediated by substrates belonging to the arachidonic acid cascade, although the data described above also suggest that the NO buffer may contribute to some extent to the reduction in the angiogenic response.

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