Genetics of Oxidative Stress in Obesity

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2014 Feb 25

PMID 24562334

Citations 23

Authors

Azahara I Ruperez

Angel Gil

Concepcion M Aguilera

Affiliations

Soon will be listed here.

Abstract

Obesity is a multifactorial disease characterized by the excessive accumulation of fat in adipose tissue and peripheral organs. Its derived metabolic complications are mediated by the associated oxidative stress, inflammation and hypoxia. Oxidative stress is due to the excessive production of reactive oxygen species or diminished antioxidant defenses. Genetic variants, such as single nucleotide polymorphisms in antioxidant defense system genes, could alter the efficacy of these enzymes and, ultimately, the risk of obesity; thus, studies investigating the role of genetic variations in genes related to oxidative stress could be useful for better understanding the etiology of obesity and its metabolic complications. The lack of existing literature reviews in this field encouraged us to gather the findings from studies focusing on the impact of single nucleotide polymorphisms in antioxidant enzymes, oxidative stress-producing systems and transcription factor genes concerning their association with obesity risk and its phenotypes. In the future, the characterization of these single nucleotide polymorphisms (SNPs) in obese patients could contribute to the development of controlled antioxidant therapies potentially beneficial for the treatment of obesity-derived metabolic complications.

Citing Articles

Energy Intake-Dependent Genetic Associations with Obesity Risk: BDNF Val66Met Polymorphism and Interactions with Dietary Bioactive Compounds.

Zhang T, Park S Antioxidants (Basel). 2025; 14(2).

PMID: 40002356 PMC: 11851519. DOI: 10.3390/antiox14020170.

Genetic interaction between oxidative stress and body mass index in a Spanish population.

Lara-Hernandez F, Melero R, Quiroz-Rodriguez M, Moya-Valera C, de Jesus Gallardo-Espinoza M, Alvarez L Redox Biol. 2025; 80:103531.

PMID: 39923398 PMC: 11849672. DOI: 10.1016/j.redox.2025.103531.

Analysis of Physiological Oxygen Concentrations in Different Abdominal Fat Layers by Body Mass Index.

Yue Q, Cao Z, Li R, Wang Y, Rui S, Yin N Aesthetic Plast Surg. 2024; 49(4):1145-1153.

PMID: 39466422 DOI: 10.1007/s00266-024-04479-z.

Multi-omic human pancreatic islet endoplasmic reticulum and cytokine stress response mapping provides type 2 diabetes genetic insights.

Sokolowski E, Kursawe R, Selvam V, Bhuiyan R, Thibodeau A, Zhao C Cell Metab. 2024; 36(11):2468-2488.e7.

PMID: 39383866 PMC: 11798411. DOI: 10.1016/j.cmet.2024.09.006.

A Case-Control Study Supports Genetic Contribution of the Gene Family in Obesity and Metabolic Dysfunction Associated Steatotic Liver Disease.

Van Dijck E, Diels S, Fransen E, Cremers T, Verrijken A, Dirinck E Antioxidants (Basel). 2024; 13(9).

PMID: 39334710 PMC: 11440101. DOI: 10.3390/antiox13091051.

References

Merry T, Tran M, Stathopoulos M, Wiede F, Fam B, Dodd G . High-fat-fed obese glutathione peroxidase 1-deficient mice exhibit defective insulin secretion but protection from hepatic steatosis and liver damage. Antioxid Redox Signal. 2013; 20(14):2114-29. DOI: 10.1089/ars.2013.5428. View

Araki S, Dobashi K, Yamamoto Y, Asayama K, Kusuhara K . Increased plasma isoprostane is associated with visceral fat, high molecular weight adiponectin, and metabolic complications in obese children. Eur J Pediatr. 2010; 169(8):965-70. DOI: 10.1007/s00431-010-1157-z. View

Delahanty R, Beeghly-Fadiel A, Xiang Y, Long J, Cai Q, Wen W . Association of obesity-related genetic variants with endometrial cancer risk: a report from the Shanghai Endometrial Cancer Genetics Study. Am J Epidemiol. 2011; 174(10):1115-26. PMC: 3246689. DOI: 10.1093/aje/kwr233. View

Chartoumpekis D, Ziros P, Psyrogiannis A, Papavassiliou A, Kyriazopoulou V, Sykiotis G . Nrf2 represses FGF21 during long-term high-fat diet-induced obesity in mice. Diabetes. 2011; 60(10):2465-73. PMC: 3178292. DOI: 10.2337/db11-0112. View

Garin M, James R, Dussoix P, Blanche H, Passa P, Froguel P . Paraoxonase polymorphism Met-Leu54 is associated with modified serum concentrations of the enzyme. A possible link between the paraoxonase gene and increased risk of cardiovascular disease in diabetes. J Clin Invest. 1997; 99(1):62-6. PMC: 507768. DOI: 10.1172/JCI119134. View

Aurelio Echart Montano M, da Cruz I, Duarte M, da Costa Krewer C, de Ugalde Marques da Rocha M, Manica-Cattani M . Inflammatory cytokines in vitro production are associated with Ala16Val superoxide dismutase gene polymorphism of peripheral blood mononuclear cells. Cytokine. 2012; 60(1):30-3. DOI: 10.1016/j.cyto.2012.05.022. View

Van Guilder G, Hoetzer G, Greiner J, Stauffer B, DeSouza C . Influence of metabolic syndrome on biomarkers of oxidative stress and inflammation in obese adults. Obesity (Silver Spring). 2006; 14(12):2127-31. DOI: 10.1038/oby.2006.248. View

Tabur S, Torun A, Sabuncu T, Turan M, Celik H, Ocak A . Non-diabetic metabolic syndrome and obesity do not affect serum paraoxonase and arylesterase activities but do affect oxidative stress and inflammation. Eur J Endocrinol. 2009; 162(3):535-41. DOI: 10.1530/EJE-09-0732. View

Ferretti G, Bacchetti T, Moroni C, Savino S, Liuzzi A, Balzola F . Paraoxonase activity in high-density lipoproteins: a comparison between healthy and obese females. J Clin Endocrinol Metab. 2004; 90(3):1728-33. DOI: 10.1210/jc.2004-0486. View

10.

Itoh H, Doi K, Tanaka T, Fukunaga Y, Hosoda K, Inoue G . Hypertension and insulin resistance: role of peroxisome proliferator-activated receptor gamma. Clin Exp Pharmacol Physiol. 1999; 26(7):558-60. DOI: 10.1046/j.1440-1681.1999.03082.x. View

11.

Block G, Dietrich M, Norkus E, Morrow J, Hudes M, Caan B . Factors associated with oxidative stress in human populations. Am J Epidemiol. 2002; 156(3):274-85. DOI: 10.1093/aje/kwf029. View

12.

Weng S, Lin T, Wang P, Chen I, Lee H, Chen S . Gly482Ser polymorphism in the peroxisome proliferator-activated receptor gamma coactivator-1alpha gene is associated with oxidative stress and abdominal obesity. Metabolism. 2009; 59(4):581-6. DOI: 10.1016/j.metabol.2009.08.021. View

13.

Ochoa M, Razquin C, Zalba G, Martinez-Gonzalez M, Martinez J, Marti A . G allele of the -930A>G polymorphism of the CYBA gene is associated with insulin resistance in obese subjects. J Physiol Biochem. 2008; 64(2):127-33. DOI: 10.1007/BF03168240. View

14.

Okauchi Y, Iwahashi H, Okita K, Yuan M, Matsuda M, Tanaka T . PGC-1alpha Gly482Ser polymorphism is associated with the plasma adiponectin level in type 2 diabetic men. Endocr J. 2008; 55(6):991-7. DOI: 10.1507/endocrj.k08e-070. View

15.

Hou Y, Xue P, Bai Y, Liu D, Woods C, Yarborough K . Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis. Free Radic Biol Med. 2011; 52(2):462-72. PMC: 3307524. DOI: 10.1016/j.freeradbiomed.2011.10.453. View

16.

Scherag A, Dina C, Hinney A, Vatin V, Scherag S, Vogel C . Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. PLoS Genet. 2010; 6(4):e1000916. PMC: 2858696. DOI: 10.1371/journal.pgen.1000916. View

17.

Chang Y, Yu Y, Shew J, Lee W, Hwang J, Chen Y . Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human. EMBO Mol Med. 2013; 5(8):1165-79. PMC: 3944459. DOI: 10.1002/emmm.201302679. View

18.

Karbownik-Lewinska M, Szosland J, Kokoszko-Bilska A, Stepniak J, Zasada K, Gesing A . Direct contribution of obesity to oxidative damage to macromolecules. Neuro Endocrinol Lett. 2012; 33(4):453-61. View

19.

Luo W, Cao J, Li J, He W . Adipose tissue-specific PPARgamma deficiency increases resistance to oxidative stress. Exp Gerontol. 2007; 43(3):154-63. DOI: 10.1016/j.exger.2007.11.002. View

20.

Huh J, Kim Y, Jeong J, Park J, Kim I, Huh K . Peroxiredoxin 3 is a key molecule regulating adipocyte oxidative stress, mitochondrial biogenesis, and adipokine expression. Antioxid Redox Signal. 2011; 16(3):229-43. PMC: 3234662. DOI: 10.1089/ars.2010.3766. View