Histamine Secretion from Mast Cells Stimulated with Somatostatin

Overview

Journal Agents Actions

Specialty Pharmacology

Date 1988 Apr 1

PMID 2455992

Citations 1

Authors

T A Kassessinoff

F L Pearce

Affiliations

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Abstract

Histamine release from isolated mast cells stimulated with somatostatin resembled that induced by other basic agents. The process was rapid, independent of added calcium or phospholipids, non-cytotoxic, species and tissue specific, not mediated through cell-fixed antibodies or glucoreceptors, and inhibited by antagonists of the polyamine receptor. Somatostatin and other polycations may then act through a common receptor or binding site on the mast cell membrane.

Citing Articles

Somatostatin effectively prevents ethanol- and NSAID-induced gastric mucosal damage in rats.

Karmeli F, Eliakim R, Okon E, Rachmilewitz D Dig Dis Sci. 1994; 39(3):617-25.

PMID: 7510607 DOI: 10.1007/BF02088351.

References

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