A Drosophila Circuit Feels the (sleep) Pressure

Overview

Journal Neuron

Publisher Cell Press

Specialty Neurology

Date 2014 Feb 25

PMID 24559667

Authors

Guliz Gurel Ozcan

Jason Rihel

Affiliations

Soon will be listed here.

Abstract

How sleep is homeostatically regulated remains a mystery. In this issue of Neuron, Donlea et al. (2014) provide evidence in Drosophila that a set of sleep-inducing neurons require Crossveinless-c, a specific Rho-GTPase-activating protein (Rho-Gap), to alter their membrane excitability in response to sleep deprivation.

References

Borbely A . A two process model of sleep regulation. Hum Neurobiol. 1982; 1(3):195-204. View

Rogulja D, Young M . Control of sleep by cyclin A and its regulator. Science. 2012; 335(6076):1617-21. PMC: 3380085. DOI: 10.1126/science.1212476. View

Bushey D, Cirelli C . From genetics to structure to function: exploring sleep in Drosophila. Int Rev Neurobiol. 2011; 99:213-44. PMC: 3172676. DOI: 10.1016/B978-0-12-387003-2.00009-4. View

Krueger J, Rector D, Roy S, Van Dongen H, Belenky G, Panksepp J . Sleep as a fundamental property of neuronal assemblies. Nat Rev Neurosci. 2008; 9(12):910-9. PMC: 2586424. DOI: 10.1038/nrn2521. View

Rihel J, Schier A . Sites of action of sleep and wake drugs: insights from model organisms. Curr Opin Neurobiol. 2013; 23(5):831-40. PMC: 3783591. DOI: 10.1016/j.conb.2013.04.010. View

Saper C, Fuller P, Pedersen N, Lu J, Scammell T . Sleep state switching. Neuron. 2010; 68(6):1023-42. PMC: 3026325. DOI: 10.1016/j.neuron.2010.11.032. View

Donlea J, Thimgan M, Suzuki Y, Gottschalk L, Shaw P . Inducing sleep by remote control facilitates memory consolidation in Drosophila. Science. 2011; 332(6037):1571-6. PMC: 4064462. DOI: 10.1126/science.1202249. View

Pilgram G, Potikanond S, van der Plas M, Fradkin L, Noordermeer J . The RhoGAP crossveinless-c interacts with Dystrophin and is required for synaptic homeostasis at the Drosophila neuromuscular junction. J Neurosci. 2011; 31(2):492-500. PMC: 6623439. DOI: 10.1523/JNEUROSCI.4732-10.2011. View

Donlea J, Pimentel D, Miesenbock G . Neuronal machinery of sleep homeostasis in Drosophila. Neuron. 2014; 81(4):860-72. PMC: 3969244. DOI: 10.1016/j.neuron.2013.12.013. View

10.

van Alphen B, Yap M, Kirszenblat L, Kottler B, van Swinderen B . A dynamic deep sleep stage in Drosophila. J Neurosci. 2013; 33(16):6917-27. PMC: 3670110. DOI: 10.1523/JNEUROSCI.0061-13.2013. View

11.

Pfeiffenberger C, Allada R . Cul3 and the BTB adaptor insomniac are key regulators of sleep homeostasis and a dopamine arousal pathway in Drosophila. PLoS Genet. 2012; 8(10):e1003003. PMC: 3464197. DOI: 10.1371/journal.pgen.1003003. View

12.

Andretic R, van Swinderen B, Greenspan R . Dopaminergic modulation of arousal in Drosophila. Curr Biol. 2005; 15(13):1165-75. DOI: 10.1016/j.cub.2005.05.025. View

13.

Alam M, Kumar S, McGinty D, Alam M, Szymusiak R . Neuronal activity in the preoptic hypothalamus during sleep deprivation and recovery sleep. J Neurophysiol. 2013; 111(2):287-99. PMC: 3921380. DOI: 10.1152/jn.00504.2013. View