Association of Biomarkers of Inflammation with Dyslipidemia and Its Components Among Mongolians in China

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Feb 22

PMID 24558466

Citations 9

Authors

Lingyan Tang

Hao Peng

Tian Xu

Aili Wang

Guiyan Wang

Weijun Tong

Yonghong Zhang

Affiliations

Soon will be listed here.

Abstract

Objective: This study aims to examine the association between inflammatory biomarkers and dyslipidemia and its components among Mongolians in China.

Methods: Data were obtained from 2544 Mongolians via standard questionnaires and blood samples in Inner Mongolia, China. High sensitivity C-reactive protein (hsCRP), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble E-selectin (sE-selectin) as well as blood lipids were examined.

Results: Individuals with dyslipidemia had higher levels of hsCRP, sICAM-1 and sE-selectin than those without dyslipidemia (all P values<0.001). Compared to the lowest quartile of inflammatory biomarkers, individuals with the highest quartile were more likely to have dyslipidemia (odds ratio, 95% confidence interval: 3.215, 2.551-4.116 for hsCRP; 1.575, 1.253-1.980 for sICAM-1; 1.495, 1.193-1.873 for sE-selectin). Moreover, hsCRP was associated with all the components of dyslipidemia, whereas, sICAM-1 was not related to high density lipoprotein cholesterol (HDL-c) or triglycerides (TAG). Additionally, sE-selectin was just associated with TAG.

Conclusion: Our study indicated that elevated plasma levels of hsCRP, sICAM-1 and sE-selectin were positively and significantly associated with increased risk of dyslipidemia among Mongolians. However, the associations were not identical for different inflammatory biomarkers with the components of dyslipidemia.

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