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Two Monoclonal Antibodies Specific for Serotype 4 Antigen of Neisseria Meningitidis

Overview
Journal Eur J Clin Microbiol Infect Dis
Publisher Springer
Specialties Infectious Diseases
Microbiology
Date 1988 Apr 1
PMID 2455642
Citations 5
Authors
H Abdillahi
B A Crowe
M Achtman
J T Poolman
Affiliations
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Abstract

Two new monoclonal antibodies (MN14G21.17 and MN14E9.15) specific for the serotype 4 antigen of meningococci were isolated. The antibodies were raised against a previously non-typable serogroup B strain from the Netherlands and were shown to react with the serotype antigen of the prototype reference strains for serotype 4 and serogroup A as well as with that of the homologous strain. Further screening of 290 serogroup A and B case isolates with the monoclonal antibodies indicated that the serotype 4 epitope was present on all 100 serogroup A strains tested, including representative isolates from 28 epidemics, and on most isolates from a recent serogroup B epidemic (1981-1983) in Cuba. In addition, 68 isolates from recent sporadic cases (1980-1986) and/or clusters of cases of serogroup B disease in many parts of Europe, the USA, the USSR and Australia were also of this serotype.

Citing Articles

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Poolman J, Abdillahi H Eur J Clin Microbiol Infect Dis. 1988; 7(2):291-2.

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Two distinct outer membrane serotype subcomplexes of Neisseria meningitidis serogroup A.

BLASIUS R, Strittmatter W, Crowe B, Achtman M Infect Immun. 1990; 58(6):2008-10.

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Characterization of serogroup A and B strains of Neisseria meningitidis with serotype 4 and 21 monoclonal antibodies and by multilocus enzyme electrophoresis.

Wedege E, Caugant D, Froholm L, Zollinger W J Clin Microbiol. 1991; 29(7):1486-92.

PMID: 1909347 PMC: 270139. DOI: 10.1128/jcm.29.7.1486-1492.1991.

Characterization of Neisseria meningitidis serogroup A strains from an outbreak in France by serotype, serosubtype, multilocus enzyme genotype and outer membrane protein pattern.

Riou J, Caugant D, Selander R, Poolman J, Guibourdenche M, Collatz E Eur J Clin Microbiol Infect Dis. 1991; 10(5):405-9.

PMID: 1908380 DOI: 10.1007/BF01968019.

Clonal and antigenic analysis of serogroup A Neisseria meningitidis with particular reference to epidemiological features of epidemic meningitis in the People's Republic of China.

Wang J, Caugant D, Li X, Hu X, Poolman J, Crowe B Infect Immun. 1992; 60(12):5267-82.

PMID: 1452360 PMC: 258306. DOI: 10.1128/iai.60.12.5267-5282.1992.

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