Porcine Cholecyst-derived Scaffold Promotes Full-thickness Wound Healing in Rabbit

Overview

Journal J Tissue Eng

Date 2014 Feb 21

PMID 24555014

Citations 4

Authors

Deepa Revi

Vadavanath Prabhakaran Vineetha

Jaseer Muhamed

Akhila Rajan

Thapasimuthu Vijayamma Anilkumar

Affiliations

Soon will be listed here.

Abstract

Graft-assisted healing is an important strategy for treating full-thickness skin wounds. This study evaluated the properties of porcine cholecyst-derived scaffold and its use for treating full-thickness skin wound in rabbit. The physical properties of cholecyst-derived scaffold were congenial for skin-graft application. Compared to a commercially available skin-graft substitute made of porcine small intestinal submucosa, the cholecyst-derived scaffold was rich in natural biomolecules like elastin and glycosaminoglycans. When used as a xenograft, it promoted healing with excess cell proliferation at early phases and acceptable collagen deposition in the later remodelling phases.

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