Drug Delivery Using Composite Scaffolds in the Context of Bone Tissue Engineering

Overview

Journal Clin Cases Miner Bone Metab

Date 2014 Feb 21

PMID 24554923

Citations 21

Authors

Cecilia Romagnoli

Federica DAsta

Maria Luisa Brandi

Affiliations

Soon will be listed here.

Abstract

Introduction: Due to the disadvantages of the current bone autograft and allograft in many clinical condition in which bone regeneration is required in large quantity, engineered biomaterials combined with growth factors, such as bone morphogenetic protein-2 (BMP-2), have been demonstrated to be an effective approach in bone tissue engineering, since they can act both as a scaffold and as a drug delivery system to promote bone repair and regeneration.

Area Covered: Recent advantages in the field of engineered scaffolds have been obtained from the investigation of composite scaffolds designed by the combination of bioceramics, especially hydroxyapatite (HA), and biodegradable polymers, such as poly (D,L-lactide-co-glycolide) (PLGA) and chitosan, in order to realize osteoconductive structures that can mimic the natural properties of bone tissue. Herein it is demonstrated that the incorporation of BMP-2 into different composite scaffolds, by encapsulation, absorption or entrapment, could be advantageous in terms of osteoinduction for new bone tissue engineered scaffolds as drug delivery systems and some of them should be further analyzed to optimized the drug release for future therapeutic applications.

Expert Opinion: New design concepts and fabrication techniques represent novel challenges for further investigations about the development of scaffolds as a drug delivery system for bone tissue regeneration.

Citing Articles

Advances and Challenges in Polymer-Based Scaffolds for Bone Tissue Engineering: A Path Towards Personalized Regenerative Medicine.

Farjaminejad S, Farjaminejad R, Hasani M, Garcia-Godoy F, Abdouss M, Marya A Polymers (Basel). 2024; 16(23).

PMID: 39684048 PMC: 11644794. DOI: 10.3390/polym16233303.

Drug eluting bioactive glass ceramics for fusion in spondylodiscitis: a pilot study.

Borde M, Menon V, Kanade U, Rajale S, Mane A, Varma H Neurosurg Rev. 2024; 47(1):80.

PMID: 38355838 DOI: 10.1007/s10143-024-02317-z.

Collagen matrix scaffolds: Future perspectives for the management of chronic liver diseases.

Martinez-Castillo M, Altamirano-Mendoza I, Zielinski R, Priebe W, Pina-Barba C, Gutierrez-Reyes G World J Clin Cases. 2023; 11(6):1224-1235.

PMID: 36926129 PMC: 10013111. DOI: 10.12998/wjcc.v11.i6.1224.

A Review on the Role of Wollastonite Biomaterial in Bone Tissue Engineering.

Zenebe C Biomed Res Int. 2022; 2022:4996530.

PMID: 36560965 PMC: 9767726. DOI: 10.1155/2022/4996530.

Modern approaches on stem cells and scaffolding technology for osteogenic differentiation and regeneration.

Kirankumar S, Gurusamy N, Rajasingh S, Sigamani V, Vasanthan J, Perales S Exp Biol Med (Maywood). 2021; 247(5):433-445.

PMID: 34648374 PMC: 8919323. DOI: 10.1177/15353702211052927.

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