Influence of Bottle-feeding on Serum Bisphenol a Levels in Infants

Overview

Journal J Korean Med Sci

Specialty General Medicine

Date 2014 Feb 20

PMID 24550655

Citations 5

Authors

Young-Jun Rhie

Hyo-Kyoung Nam

Yeon Joung Oh

Ho-Seong Kim

Kee-Hyoung Lee

Affiliations

Soon will be listed here.

Abstract

Exposure to endocrine disrupting chemicals (EDCs), particularly during developmental periods, gives rise to a variety of adverse health outcomes. Bisphenol A (BPA) is a well-known EDC commonly found in plastic products including food and water containers, baby bottles, and metal can linings. This study investigates infant exposure to BPA and the effect of bottle-feeding on serum BPA levels in infants. Serum BPA levels in normal healthy infants 6 to 15 months of age (n=60) were evaluated by a competitive ELISA. BPA was detected in every study sample. Serum BPA levels of bottle-fed infants (n=30) were significantly higher than those of breast-fed infants (n=30) (96.58±102.36 vs 45.53±34.05 pg/mL, P=0.014). There were no significant differences in serum BPA levels between boys (n=31) and girls (n=29). No significant correlations were found between serum BPA levels and age, body weight, birth weight, and gestational age. Bottle-feeding seems to increase the risk of infant exposure to BPA. Establishment of health policies to reduce or prevent BPA exposure in infants is necessary.

Citing Articles

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Assessment of Bottle-Feeding Practices in Kassala, Eastern Sudan: A Community-Based Study.

Hassan A, Taha Z, Abdulla M, Ali A, Adam I Open Access Maced J Med Sci. 2019; 7(4):651-656.

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Global Assessment of Bisphenol A in the Environment: Review and Analysis of Its Occurrence and Bioaccumulation.

Corrales J, Kristofco L, Steele W, Yates B, Breed C, Williams E Dose Response. 2015; 13(3):1559325815598308.

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Serum Bisphenol A Level in Boys with Cryptorchidism: A Step to Male Infertility?.

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Bisphenol A exposure pathways in early childhood: Reviewing the need for improved risk assessment models.

Healy B, English K, Jagals P, Sly P J Expo Sci Environ Epidemiol. 2015; 25(6):544-56.

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References

Hanson M, Gluckman P . Developmental origins of health and disease: new insights. Basic Clin Pharmacol Toxicol. 2008; 102(2):90-3. DOI: 10.1111/j.1742-7843.2007.00186.x. View

Sakurai K, Kawazuma M, Adachi T, Harigaya T, Saito Y, Hashimoto N . Bisphenol A affects glucose transport in mouse 3T3-F442A adipocytes. Br J Pharmacol. 2004; 141(2):209-14. PMC: 1574186. DOI: 10.1038/sj.bjp.0705520. View

Calafat A, Ye X, Wong L, Reidy J, Needham L . Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004. Environ Health Perspect. 2008; 116(1):39-44. PMC: 2199288. DOI: 10.1289/ehp.10753. View

Hugo E, Brandebourg T, Woo J, Loftus J, Alexander J, Ben-Jonathan N . Bisphenol A at environmentally relevant doses inhibits adiponectin release from human adipose tissue explants and adipocytes. Environ Health Perspect. 2008; 116(12):1642-7. PMC: 2599757. DOI: 10.1289/ehp.11537. View

Matsumoto J, Yokota H, Yuasa A . Developmental increases in rat hepatic microsomal UDP-glucuronosyltransferase activities toward xenoestrogens and decreases during pregnancy. Environ Health Perspect. 2002; 110(2):193-6. PMC: 1240735. DOI: 10.1289/ehp.02110193. View

Krishnan A, Stathis P, Permuth S, Tokes L, Feldman D . Bisphenol-A: an estrogenic substance is released from polycarbonate flasks during autoclaving. Endocrinology. 1993; 132(6):2279-86. DOI: 10.1210/endo.132.6.8504731. View

Takeuchi T, Tsutsumi O . Serum bisphenol a concentrations showed gender differences, possibly linked to androgen levels. Biochem Biophys Res Commun. 2002; 291(1):76-8. DOI: 10.1006/bbrc.2002.6407. View

Newbold R, Padilla-Banks E, Snyder R, Phillips T, Jefferson W . Developmental exposure to endocrine disruptors and the obesity epidemic. Reprod Toxicol. 2007; 23(3):290-6. PMC: 1931509. DOI: 10.1016/j.reprotox.2006.12.010. View

Welshons W, Thayer K, Judy B, Taylor J, Curran E, Vom Saal F . Large effects from small exposures. I. Mechanisms for endocrine-disrupting chemicals with estrogenic activity. Environ Health Perspect. 2003; 111(8):994-1006. PMC: 1241550. DOI: 10.1289/ehp.5494. View

10.

Snyder R, Maness S, Gaido K, Welsch F, Sumner S, Fennell T . Metabolism and disposition of bisphenol A in female rats. Toxicol Appl Pharmacol. 2000; 168(3):225-34. DOI: 10.1006/taap.2000.9051. View

11.

Carwile J, Luu H, Bassett L, Driscoll D, Yuan C, Chang J . Polycarbonate bottle use and urinary bisphenol A concentrations. Environ Health Perspect. 2009; 117(9):1368-72. PMC: 2737011. DOI: 10.1289/ehp.0900604. View

12.

Lang I, Galloway T, Scarlett A, Henley W, Depledge M, Wallace R . Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. JAMA. 2008; 300(11):1303-10. DOI: 10.1001/jama.300.11.1303. View

13.

Le H, Carlson E, Chua J, Belcher S . Bisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons. Toxicol Lett. 2007; 176(2):149-56. PMC: 2254523. DOI: 10.1016/j.toxlet.2007.11.001. View

14.

Volkel W, Colnot T, Csanady G, Filser J, Dekant W . Metabolism and kinetics of bisphenol a in humans at low doses following oral administration. Chem Res Toxicol. 2002; 15(10):1281-7. DOI: 10.1021/tx025548t. View

15.

Ashby J, Tinwell H . Uterotrophic activity of bisphenol A in the immature rat. Environ Health Perspect. 1998; 106(11):719-20. PMC: 1533494. DOI: 10.1289/ehp.98106719. View

16.

Brede C, Fjeldal P, Skjevrak I, Herikstad H . Increased migration levels of bisphenol A from polycarbonate baby bottles after dishwashing, boiling and brushing. Food Addit Contam. 2003; 20(7):684-9. DOI: 10.1080/0265203031000119061. View

17.

Rubin B, Murray M, Damassa D, King J, Soto A . Perinatal exposure to low doses of bisphenol A affects body weight, patterns of estrous cyclicity, and plasma LH levels. Environ Health Perspect. 2001; 109(7):675-80. PMC: 1240370. DOI: 10.1289/ehp.01109675. View

18.

Takeuchi T, Tsutsumi O, Ikezuki Y, Takai Y, Taketani Y . Positive relationship between androgen and the endocrine disruptor, bisphenol A, in normal women and women with ovarian dysfunction. Endocr J. 2004; 51(2):165-9. DOI: 10.1507/endocrj.51.165. View

19.

Miyawaki J, Sakayama K, Kato H, Yamamoto H, Masuno H . Perinatal and postnatal exposure to bisphenol a increases adipose tissue mass and serum cholesterol level in mice. J Atheroscler Thromb. 2007; 14(5):245-52. DOI: 10.5551/jat.e486. View

20.

Howdeshell K, Hotchkiss A, Thayer K, Vandenbergh J, Vom Saal F . Exposure to bisphenol A advances puberty. Nature. 1999; 401(6755):763-4. DOI: 10.1038/44517. View