Invasive Fungal Diseases During First Induction Chemotherapy Affect Complete Remission Achievement and Long-term Survival of Patients with Acute Myeloid Leukemia

Overview

Journal Leuk Res

Date 2014 Feb 19

PMID 24534569

Citations 17

Authors

Corrado Girmenia

Alessandra Micozzi

Alfonso Piciocchi

Giuseppe Gentile

Luigi Di Caprio

Daniela Nasso

Clara Minotti

Saveria Capria

Claudio Cartoni

Giuliana Alimena

Giovanna Meloni

Sergio Amadori

Robin Foa

Adriano Venditti

Affiliations

Soon will be listed here.

Abstract

We retrospectively evaluated, in a logistic-regression-model, the role of proven/probable invasive fungal diseases (PP-IFD), occurring during first induction chemotherapy, on the achievement of complete remission (CR) and overall survival (OS) in 198 acute myeloid leukemia (AML) patients. A PP-IFD was documented in 34 (17.2%) patients. Younger age, good performance status at AML diagnosis and no development of a PP-IFD (OR 4.09, 95% CI 1.71-9.81, p<0.0001) were independent factors associated to CR achievement. Younger age, good performance status, favorable genetic risk and no development of PP-IFD (HR 1.86, 95% CI 1.20-2.88, p=0.005) were independent factors associated to OS at 3 years.

Citing Articles

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Bergamasco M, Pereira C, Arrais-Rodrigues C, Ferreira D, Baiocchi O, Kerbauy F J Fungi (Basel). 2021; 7(8).

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