Matrix Metalloproteinases: the Gene Expression Signatures of Head and Neck Cancer Progression

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2014 Feb 18

PMID 24531055

Citations 23

Authors

Shinji Iizuka

Naozumi Ishimaru

Yasusei Kudo

Affiliations

Soon will be listed here.

Abstract

Extracellular matrix degradation by matrix metalloproteinases (MMPs) plays a pivotal role in cancer progression by promoting motility, invasion and angiogenesis. Studies have shown that MMP expression is increased in head and neck squamous cell carcinomas (HNSCCs), one of the most common cancers in the world, and contributes to poor outcome. In this review, we examine the expression pattern of MMPs in HNSCC by microarray datasets and summarize the current knowledge of MMPs, specifically MMP-1, -3, -7 -10, -12, -13, 14 and -19, that are highly expressed in HNSCCs and involved cancer invasion and angiogenesis.

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