Tooth, Hair and Claw: Comparing Epithelial Stem Cell Niches of Ectodermal Appendages

Overview

Journal Exp Cell Res

Specialty Cell Biology

Date 2014 Feb 18

PMID 24530577

Citations 8

Authors

Adrien Naveau

Kerstin Seidel

Ophir D Klein

Affiliations

Soon will be listed here.

Abstract

The vertebrate ectoderm gives rise to organs that produce mineralized or keratinized substances, including teeth, hair, and claws. Most of these ectodermal derivatives grow continuously throughout the animal׳s life and have active pools of adult stem cells that generate all the necessary cell types. These organs provide powerful systems for understanding the mechanisms that enable stem cells to regenerate or renew ectodermally derived tissues, and remarkable progress in our understanding of these systems has been made in recent years using mouse models. We briefly compare what is known about stem cells and their niches in incisors, hair follicles, and claws, and we examine expression of Gli1 as a potential example of a shared stem cell marker. We summarize some of the features, structures, and functions of the stem cell niches in these ectodermal derivatives; definition of the basic elements of the stem cell niches in these organs will provide guiding principles for identification and characterization of the niche in similar systems.

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References

Kandyba E, Leung Y, Chen Y, Widelitz R, Chuong C, Kobielak K . Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation. Proc Natl Acad Sci U S A. 2013; 110(4):1351-6. PMC: 3557042. DOI: 10.1073/pnas.1121312110. View

Oro A, Higgins K . Hair cycle regulation of Hedgehog signal reception. Dev Biol. 2003; 255(2):238-48. DOI: 10.1016/s0012-1606(02)00042-8. View

Jheon A, Seidel K, Biehs B, Klein O . From molecules to mastication: the development and evolution of teeth. Wiley Interdiscip Rev Dev Biol. 2013; 2(2):165-82. PMC: 3632217. DOI: 10.1002/wdev.63. View

Dassule H, Lewis P, Bei M, Maas R, McMahon A . Sonic hedgehog regulates growth and morphogenesis of the tooth. Development. 2000; 127(22):4775-85. DOI: 10.1242/dev.127.22.4775. View

Wang L, Liu Z, Gambardella L, Delacour A, Shapiro R, Yang J . Regular articles: conditional disruption of hedgehog signaling pathway defines its critical role in hair development and regeneration. J Invest Dermatol. 2000; 114(5):901-8. DOI: 10.1046/j.1523-1747.2000.00951.x. View

Chang J, Wang C, Jin C, Yang C, Huang Y, Liu J . Self-renewal and multilineage differentiation of mouse dental epithelial stem cells. Stem Cell Res. 2013; 11(3):990-1002. PMC: 3952636. DOI: 10.1016/j.scr.2013.06.008. View

Jheon A, Li C, Wen T, Michon F, Klein O . Expression of microRNAs in the stem cell niche of the adult mouse incisor. PLoS One. 2011; 6(9):e24536. PMC: 3169592. DOI: 10.1371/journal.pone.0024536. View

Zhao W, Neufeld D . Bone regrowth in young mice stimulated by nail organ. J Exp Zool. 1995; 271(2):155-9. DOI: 10.1002/jez.1402710212. View

Paus R, Muller-Rover S, van der Veen C, Maurer M, Eichmuller S, Ling G . A comprehensive guide for the recognition and classification of distinct stages of hair follicle morphogenesis. J Invest Dermatol. 1999; 113(4):523-32. DOI: 10.1046/j.1523-1747.1999.00740.x. View

10.

St-Jacques B, Dassule H, Karavanova I, Botchkarev V, Li J, Danielian P . Sonic hedgehog signaling is essential for hair development. Curr Biol. 1998; 8(19):1058-68. DOI: 10.1016/s0960-9822(98)70443-9. View

11.

Kumar A, Brockes J . Nerve dependence in tissue, organ, and appendage regeneration. Trends Neurosci. 2012; 35(11):691-9. DOI: 10.1016/j.tins.2012.08.003. View

12.

Soukup V, Epperlein H, Horacek I, cerny R . Dual epithelial origin of vertebrate oral teeth. Nature. 2008; 455(7214):795-8. DOI: 10.1038/nature07304. View

13.

Hirai Y, Nose A, Kobayashi S, Takeichi M . Expression and role of E- and P-cadherin adhesion molecules in embryonic histogenesis. II. Skin morphogenesis. Development. 1989; 105(2):271-7. DOI: 10.1242/dev.105.2.271. View

14.

Gritli-Linde A, Bei M, Maas R, Zhang X, Linde A, McMahon A . Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization. Development. 2002; 129(23):5323-37. DOI: 10.1242/dev.00100. View

15.

Plikus M, Mayer J, de la Cruz D, Baker R, Maini P, Maxson R . Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature. 2008; 451(7176):340-4. PMC: 2696201. DOI: 10.1038/nature06457. View

16.

Thesleff I, Vaahtokari A, Partanen A . Regulation of organogenesis. Common molecular mechanisms regulating the development of teeth and other organs. Int J Dev Biol. 1995; 39(1):35-50. View

17.

Tunggal J, Helfrich I, Schmitz A, Schwarz H, Gunzel D, Fromm M . E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J. 2005; 24(6):1146-56. PMC: 556407. DOI: 10.1038/sj.emboj.7600605. View

18.

Muller-Rover S, Handjiski B, van der Veen C, Eichmuller S, Foitzik K, McKay I . A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. J Invest Dermatol. 2001; 117(1):3-15. DOI: 10.1046/j.0022-202x.2001.01377.x. View

19.

Ohazama A, Haworth K, Ota M, Khonsari R, Sharpe P . Ectoderm, endoderm, and the evolution of heterodont dentitions. Genesis. 2010; 48(6):382-9. DOI: 10.1002/dvg.20634. View

20.

Crosnier C, Stamataki D, Lewis J . Organizing cell renewal in the intestine: stem cells, signals and combinatorial control. Nat Rev Genet. 2006; 7(5):349-59. DOI: 10.1038/nrg1840. View