Anarchic Centromeres: Deciphering Order from Apparent Chaos

Overview

Journal Curr Opin Cell Biol

Publisher Elsevier

Specialty Cell Biology

Date 2014 Feb 18

PMID 24529245

Citations 19

Authors

Sandra Catania

Robin C Allshire

Affiliations

Soon will be listed here.

Abstract

Specialised chromatin in which canonical histone H3 is replaced by CENP-A, an H3 related protein, is a signature of active centromeres and provides the foundation for kinetochore assembly. The location of centromeres is not fixed since centromeres can be inactivated and new centromeres can arise at novel locations independently of specific DNA sequence elements. Therefore, the establishment and maintenance of CENP-A chromatin and kinetochores provide an exquisite example of genuine epigenetic regulation. The composition of CENP-A nucleosomes is contentious but several studies suggest that, like regular H3 particles, they are octamers. Recent analyses have provided insight into how CENP-A is recognised and propagated, identified roles for post-translational modifications and dissected how CENP-A recruits other centromere proteins to mediate kinetochore assembly.

Citing Articles

Structural basis for Mis18 complex assembly and its implications for centromere maintenance.

Thamkachy R, Medina-Pritchard B, Park S, Chiodi C, Zou J, de la Torre-Barranco M EMBO Rep. 2024; 25(8):3348-3372.

PMID: 38951710 PMC: 11315898. DOI: 10.1038/s44319-024-00183-w.

Cdc48 and its co-factor Ufd1 extract CENP-A from centromeric chromatin and can induce chromosome elimination in the fission yeast Schizosaccharomyces pombe.

Nakase Y, Murakami H, Suma M, Nagano K, Wakuda A, Kitagawa T Biol Open. 2024; 13(4).

PMID: 38526189 PMC: 11033524. DOI: 10.1242/bio.060287.

Interactions With Histone H3 & Tools to Study Them.

Scott W, Campos E Front Cell Dev Biol. 2020; 8:701.

PMID: 32850821 PMC: 7411163. DOI: 10.3389/fcell.2020.00701.

Auto-inhibition of Mif2/CENP-C ensures centromere-dependent kinetochore assembly in budding yeast.

Killinger K, Bohm M, Steinbach P, Hagemann G, Bluggel M, Janen K EMBO J. 2020; 39(14):e102938.

PMID: 32515113 PMC: 7360964. DOI: 10.15252/embj.2019102938.

Fission Yeast CENP-C (Cnp3) Plays a Role in Restricting the Site of CENP-A Accumulation.

Suma M, Kitagawa T, Nakase Y, Nakazawa N, Yanagida M, Matsumoto T G3 (Bethesda). 2018; 8(8):2723-2733.

PMID: 29925533 PMC: 6071599. DOI: 10.1534/g3.118.200486.

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