Phytochemicals and Naturally Derived Substances for Wound Healing

Overview

Journal Adv Wound Care (New Rochelle)

Date 2014 Feb 15

PMID 24527308

Citations 15

Authors

Raja K Sivamani

Brian R Ma

Lisa N Wehrli

Emanual Maverakis

Affiliations

Soon will be listed here.

Abstract

Background: Complementary and alternative medicines (CAMs) are widely used by the general public. Natural products including plant-derived extracts (phytochemicals) and naturally derived substances, such as honey, are an important component of CAM. Here, we review the evidence for their use in wound care.

The Problem: Wound healing is complex and disruption of this process can lead to considerable morbidity, including chronic wounds, infection, and scarring. Natural products have a long history of use in wound care, but there are only a few rigorous studies. With the growing interest in the use of natural products and the belief that they are safer than standard therapies, it is vital to understand the current knowledge of their efficacy and side effects.

Basic/clinical Science Advances: Natural products possess antioxidant, anti-inflammatory, angiogenic, and cell synthesis-modulating components among many others. However, this complex composition of chemicals may increase the risk for irritant or allergic side effects.

Clinical Care Relevance: Natural products can be much cheaper than conventional treatments, but further study is needed to better understand their efficacy. The type of wound and the potential for side effects need to be carefully considered when choosing a treatment.

Conclusion: The research to date is supportive of the use of natural products in wound care. Patients need to be cautioned of potential side effects. Collaborative research between allopathic medicine and medical systems that frequently employ phytochemicals and naturally derived substances, such as Ayurveda and naturopathy, will provide a better understanding of how to integrate natural products into wound care.

Citing Articles

Compounds of Marine Origin with Possible Applications as Healing Agents.

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Effect of snail mucus on angiogenesis during wound healing.

Rosanto Y, Hasan C, Rahardjo R, Pangestiningsih T F1000Res. 2024; 10:181.

PMID: 38912381 PMC: 11190653. DOI: 10.12688/f1000research.51297.2.

Evidence for Natural Products as Alternative Wound-Healing Therapies.

Moses R, Prescott T, Mas-Claret E, Steadman R, Moseley R, Sloan A Biomolecules. 2023; 13(3).

PMID: 36979379 PMC: 10046143. DOI: 10.3390/biom13030444.

The wound healing effect of botanicals and pure natural substances used in in vivo models.

El-Sherbeni S, Negm W Inflammopharmacology. 2023; 31(2):755-772.

PMID: 36811778 PMC: 10140094. DOI: 10.1007/s10787-023-01157-5.

Pharmacodynamic appraisal of wound-healing herbs of .

Kumar V, Manoj Nesari T, Ghildiyal S, Sherkhane R Ayu. 2023; 42(1):1-18.

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