Chinese Medicine Shensongyangxin is Effective for Patients with Bradycardia: Results of a Randomized, Double-blind, Placebo-controlled Multicenter Trial

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2014 Feb 15

PMID 24527049

Citations 22

Authors

Yunfang Liu

Ning Li

Zhenhua Jia

Feng Lu

Jielin Pu

Affiliations

Soon will be listed here.

Abstract

To evaluate the efficacy and safety of Shensong Yangxin (SSYX) in patients with bradycardia arrhythmias, a randomized, double-blind, and placebo-controlled study was conducted. Patients with bradycardia were randomly assigned to receive either SSYX (trial group, n = 115) or placebo (control group, n = 104) for 4 weeks. ECG, 24-hour continuous ECG recording, echocardiography, and hepatic and renal function were evaluated at baseline and after treatment. Results showed that the average heart rate, the fastest heart rate, and the lowest heart rate in the trial group were all significantly higher than those in the control group at the end of treatment (P < 0.05 or 0.01, resp.). Compared with pretreatment, the average heart rate, the fastest heart rate, and the lowest heart rate in the trial group all increased significantly after treatment (P < 0.05 or 0.01, resp.). Both the efficacy and the symptom scores in the trial group were significantly better than those in the control group after treatment (both having P < 0.01). No severe adverse effects were reported. In conclusion, SSYX treatment significantly increased the heart rate in patients with bradycardia without severe side effects. The exact mechanisms remain to be further explored.

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References

Essebag V, Hadjis T, Platt R, Pilote L . Amiodarone and the risk of bradyarrhythmia requiring permanent pacemaker in elderly patients with atrial fibrillation and prior myocardial infarction. J Am Coll Cardiol. 2003; 41(2):249-54. DOI: 10.1016/s0735-1097(02)02709-2. View

Hendeles L, Weinberger M, Milavetz G, Hill 3rd M, Vaughan L . Food-induced "dose-dumping" from a once-a-day theophylline product as a cause of theophylline toxicity. Chest. 1985; 87(6):758-65. DOI: 10.1378/chest.87.6.758. View

Groh W . Arrhythmias in the muscular dystrophies. Heart Rhythm. 2012; 9(11):1890-5. DOI: 10.1016/j.hrthm.2012.06.038. View

Ufberg J, Clark J . Bradydysrhythmias and atrioventricular conduction blocks. Emerg Med Clin North Am. 2005; 24(1):1-9, v. DOI: 10.1016/j.emc.2005.08.006. View

Aronow W . Management of atrial fibrillation in the elderly. Minerva Med. 2009; 100(1):3-24. View

Zipes D, Borggrefe M, Buxton A, Chaitman B, Fromer M, Gregoratos G . ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of.... J Am Coll Cardiol. 2006; 48(5):e247-346. DOI: 10.1016/j.jacc.2006.07.010. View

Li N, Ma K, Wu X, Sun Q, Zhang Y, Pu J . Effects of Chinese herbs on multiple ion channels in isolated ventricular myocytes. Chin Med J (Engl). 2007; 120(12):1068-74. View

Shi L, Yang X, Liu X, Zong M, Wu Y . [Effects of ShenSongYangXin on action potential and some current channels in isolated rabbit pulmonary vein cardiomyocytes]. Zhonghua Yi Xue Za Zhi. 2010; 89(30):2142-6. View

Li N, Huo Y, Ma K, Sun Q, Pu J . [Effects of solution of dry powder of ShenSongYangXin capsule on sodium current and L-type calcium current in ventricular myocytes: experiment with guinea pig]. Zhonghua Yi Xue Za Zhi. 2007; 87(14):995-8. View

10.

Rucinski P, Rubaj A, Kutarski A . Pharmacotherapy changes following pacemaker implantation in patients with bradycardia-tachycardia syndrome. Expert Opin Pharmacother. 2006; 7(16):2203-13. DOI: 10.1517/14656566.7.16.2203. View

11.

Chai S, Wang S, Yao L, Wu A, Liu Y, Rao C . [Effect of shensongyangxin capsule on myocardial remodeling and ventricular fibrillation threshold value in rat with coronary artery ligation]. Zhongguo Zhong Yao Za Zhi. 2009; 34(16):2101-4. View

12.

Wang A, Pu J, Qi X, Miao W, Hou Z, Cong H . [Evaluation of shensongyangxin capsules in the treatment of paroxysmal atrial fibrillation: a randomized, double-blind and controlled multicenter trial]. Zhonghua Yi Xue Za Zhi. 2011; 91(24):1677-81. View

13.

Holly R, Shaffrath J, Amsterdam E . Electrocardiographic alterations associated with the hearts of athletes. Sports Med. 1998; 25(3):139-48. DOI: 10.2165/00007256-199825030-00001. View

14.

Durham D, Worthley L . Cardiac arrhythmias: diagnosis and management. The bradycardias. Crit Care Resusc. 2006; 4(1):54-60. View

15.

Brady Jr W, Harrigan R . Diagnosis and management of bradycardia and atrioventricular block associated with acute coronary ischemia. Emerg Med Clin North Am. 2001; 19(2):371-84, xi-xii. DOI: 10.1016/s0733-8627(05)70189-9. View

16.

Zou J, Zhang J, Jia Z, Cao K . Evaluation of the traditional Chinese Medicine Shensongyangxin capsule on treating premature ventricular contractions: a randomized, double-blind, controlled multicenter trial. Chin Med J (Engl). 2011; 124(1):76-83. View

17.

Feng L, Gong J, Jin Z, Li N, Sun L, Wu Y . Electrophysiological effects of Chinese medicine Shen song Yang xin (SSYX) on Chinese miniature swine heart and isolated guinea pig ventricular myocytes. Chin Med J (Engl). 2009; 122(13):1539-43. View

18.

Zheng A, Moritani T . Effect of the combination of ginseng, oriental bezoar and glycyrrhiza on autonomic nervous activity and immune system under mental arithmetic stress. J Nutr Sci Vitaminol (Tokyo). 2008; 54(3):244-9. DOI: 10.3177/jnsv.54.244. View

19.

Das G . Therapeutic review. Cardiac effects of atropine in man: an update. Int J Clin Pharmacol Ther Toxicol. 1989; 27(10):473-7. View