Concise Enantiospecific Total Synthesis of Tubingensin A

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2014 Feb 15

PMID 24524351

Citations 26

Authors

Adam E Goetz

Amanda L Silberstein

Michael A Corsello

Neil K Garg

Affiliations

Soon will be listed here.

Abstract

We report the enantiospecific total synthesis of (+)-tubingensin A. Our synthesis features an aryne cyclization to efficiently introduce the vicinal quaternary stereocenters of the natural product and proceeds in only nine steps (longest linear sequence) from known compounds.

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