Electroretinal Changes in the Presence of a Carbonic Anhydrase Inhibitor

Overview

Journal Ophthalmologica

Publisher Karger

Specialty Ophthalmology

Date 1988 Jan 1

PMID 2452395

Citations 4

Authors

G C Broeders

R Parmer

W W Dawson

Affiliations

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Abstract

A specific carbonic anhydrase activity inhibitor (methazolamide) was injected into one vitreous body each of 4 New Zealand White rabbits. Electroretinograms (ERG) were recorded before and several times after the methazolamide injection. The stimulus levels maximized the rod and cone response characteristics of the rabbit ERG. The effects of methazolamide were followed over 5 h. During this time, the electroretinograms showed a decline in amplitude of both a and b waves at both stimulus levels. The data support the involvement of carbonic anhydrase in the excitatory physiological events in the retina. Preliminary evidence indicates a slow recovery of the carbonic-anhydrase-inhibited ERG.

Citing Articles

Modes of Accessing Bicarbonate for the Regulation of Membrane Guanylate Cyclase (ROS-GC) in Retinal Rods and Cones.

Makino C, Duda T, Pertzev A, Isayama T, Geva P, Sandberg M eNeuro. 2019; 6(1).

PMID: 30783616 PMC: 6378327. DOI: 10.1523/ENEURO.0393-18.2019.

Bicarbonate and Ca(2+) Sensing Modulators Activate Photoreceptor ROS-GC1 Synergistically.

Duda T, Pertzev A, Makino C, Sharma R Front Mol Neurosci. 2016; 9:5.

PMID: 26858600 PMC: 4729890. DOI: 10.3389/fnmol.2016.00005.

Bicarbonate Modulates Photoreceptor Guanylate Cyclase (ROS-GC) Catalytic Activity.

Duda T, Wen X, Isayama T, Sharma R, Makino C J Biol Chem. 2015; 290(17):11052-60.

PMID: 25767116 PMC: 4409265. DOI: 10.1074/jbc.M115.650408.

The effects of acetazolamide on electroretinogram B-wave amplitude in albino rabbits.

Odom J, WEINSTEIN G, Nork T, Zavage D, Brown S, Hobson R Doc Ophthalmol. 1989; 72(1):55-9.

PMID: 2806036 DOI: 10.1007/BF00155214.