Preferential Deposition of Visceral Adipose Tissue Occurs Due to Physical Inactivity
Overview
Affiliations
We hypothesised that strict inactivity (bed rest) would lead to regional differences in fat deposition. Twenty-four male subjects underwent 60 d bed rest and remained inactive (n = 9), performed resistance exercise plus whole-body vibration (RVE; n = 7) or resistance exercise only (RE; n = 8). Fat mass was assessed via dual X-ray absorptiometry. In the inactive subjects, fat deposition differed between body regions (P = 0.0005) with android region visceral adipose tissue increasing the most (+29% at the end of bed rest), followed by remainder of the trunk (from chin to the iliac crest; +10%) and the arms and legs (both +7%). Insulin sensitivity reduced in the inactive subjects at the end of bed rest (P = 0.036). RE did not have a significant impact on regional fat mass changes (P ⩾ 0.055). In RVE, increases in visceral adipose tissue (-14%; P = 0.028 vs inactive subjects) and in the arms (arms -8%, P = 0.011 vs inactive) were not seen. We conclude that inactivity leads to a preferential increase in visceral adipose tissue.
Iijima H, Ambrosio F, Matsui Y J Physiol. 2023; 603(1):45-67.
PMID: 38099335 PMC: 11702919. DOI: 10.1113/JP285349.
Physiology of sedentary behavior.
Pinto A, Bergouignan A, Dempsey P, Roschel H, Owen N, Gualano B Physiol Rev. 2023; 103(4):2561-2622.
PMID: 37326297 PMC: 10625842. DOI: 10.1152/physrev.00022.2022.
Molla M, Wolde H, Teferi E, Kibret A Front Oncol. 2023; 13:1150303.
PMID: 37124535 PMC: 10130526. DOI: 10.3389/fonc.2023.1150303.
Exercise Restores Hypothalamic Health in Obesity by Reshaping the Inflammatory Network.
Della Guardia L, Codella R Antioxidants (Basel). 2023; 12(2).
PMID: 36829858 PMC: 9951965. DOI: 10.3390/antiox12020297.
Metabolic Risk Factors in Young Men With Healthy Body Fat But Different Level of Physical Activity.
Keska A, Tkaczyk J, Malara M, Iwanska D Am J Mens Health. 2022; 16(1):15579883211070384.
PMID: 35045742 PMC: 8785314. DOI: 10.1177/15579883211070384.