Core Drug-drug Interaction Alerts for Inclusion in Pediatric Electronic Health Records with Computerized Prescriber Order Entry

Objective: The study aims to develop a core set of pediatric drug-drug interaction (DDI) pairs for which electronic alerts should be presented to prescribers during the ordering process.

Methods: A clinical decision support working group composed of Children's Hospital Association (CHA) members was developed. CHA Pharmacists and Chief Medical Information Officers participated.

Results: Consensus was reached on a core set of 19 DDI pairs that should be presented to pediatric prescribers during the order process.

Conclusions: We have provided a core list of 19 high value drug pairs for electronic drug-drug interaction alerts to be recommended for inclusion as high value alerts in prescriber order entry software used with a pediatric patient population. We believe this list represents the most important pediatric drug interactions for practical implementation within computerized prescriber order entry systems.