Protective Effect of Melatonin Against Inequality-Induced Da Mages on Testicular Tissue and Sper M Para Meters

Overview

Journal Int J Fertil Steril

Specialty Reproductive Medicine

Date 2014 Feb 13

PMID 24520501

Citations 5

Authors

Shiva Nasiraei-Moghadam Nasiraei-Moghadam

Kazem Parivar

Abolhasan Ahmadiani

Mansoureh Movahhedin

Mohammad Reza Vaez Mahdavi

Affiliations

Soon will be listed here.

Abstract

Background: The goals of the study are evaluation the effects of food deprivation and isolation situation as a social stress on fertility; and in the following, investigation of the improving effect of melatonin as an antioxidant component.

Materials And Methods: In this experimental study, We investigated histopathological and serological effects of melatonin and social stress (food deprivation and isolation) on different features of sperm and testicular tissue among 42 male rats in 7 groups including control, sham, melatonin received (M), food deprivation (FD), Food deprivation and melatonin treatment (FDM), Food deprivation and isolation situation (FDi), and Food deprivation and melatonin treatment and isolation situation (FDMi) groups. Epididymal sperms of all rats were also counted. Histopathological evaluation of the testes was done under a light microscopy to determine the number of spermiogenic cells. Serological evaluation of testosterone, corticosterone, and melatonin was performed, as well. For statistical analysis, oneway ANOVA and Tukey's post hoc test were used, and the value of p≤0.05 was considered statistically significance.

Results: The result showed that food deprivation increased the number of abnormal, immotile, and dead sperms, while decreased the number of normal sperms (p<0.05). Isolation could improve sperm motility and viability, while enhanced the number of sper- matogenic cells. Melatonin had a protective effect on sperm count, motility, and viability, while reduced sperm abnormality.

Conclusion: Our results demonstrated that melatonin treatment and isolation situation improve the parameters related to epididymal sperms and spermatogenic cells after food deprivation.

Citing Articles

[Meta-analysis of experimental studies of the effect of melatonin monotherapy on the levels of thyroid hormones and glucocorticoids in rats kept under standard condition].

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Endocrine disorders and fertility and pregnancy: An update.

Bendarska-Czerwinska A, Zmarzly N, Morawiec E, Panfil A, Brys K, Czarniecka J Front Endocrinol (Lausanne). 2023; 13:970439.

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The effect of the melatonin on cryopreserved mouse testicular cells.

Saki G, Mirhoseini M, Hemadi M, Khodadadi A, Beygom Talebpour Amiri F Int J Reprod Biomed. 2016; 14(1):23-8.

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Sodium metabisulfite-induced changes on testes, spermatogenesis and epididymal morphometric values in adult rats.

Shekarforoush S, Ebrahimi Z, Hoseini M Int J Reprod Biomed. 2016; 13(12):765-70.

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Melatonin: shedding light on infertility?--A review of the recent literature.

Fernando S, Rombauts L J Ovarian Res. 2014; 7:98.

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